The CADRE project will base its research using data sets collected through ADSP – the Alzheimer’s Disease Sequencing Project – along with additional data sets that we are currently exploring, with the purpose of securing diversity in this large-scale research.
CADRE members have played central roles in the creation of many of the research institutes involved in this effort, and many members serve as those institutions’ investigators and leaders.
Alzheimer’s Disease Sequencing Project (ADSP)
The CADRE group’s analysis will be applied to genetic data already collected through ADSP, as well as new data from samples being collected by CADRE members as part of a distinct effort to diversify the ADSP collection. Additional samples will be added as collaborations with investigators and institutions continue. The goal is to add ethnic diversity to enhance understanding of a disease that we know has varied impacts on people with diverse ancestry.
The ADSP is comprised of five independent groups at eight medical centers. All CADRE member institutions are part of ADSP.
The ADSP is supported by the National Institute on Aging and the National Human Genome Research Institute. The NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS) at the University of Pennsylvania acts as a coordinating center for the ADSP.
All genetic sequencing data collected as part of the CADRE project – from new samples or existing samples that will be re-sequenced – will be deposited with ADSP/NIAGADS. All ADSP data are accessible to researchers through a process managed by NIAGADS. To learn more about accessible data, link to the NIAGADS website here.
Additional data sets
Beyond the data sets collected through ADSP and CADRE group efforts, we also are exploring collaborations with genetics researchers in Taiwan, Japan, China, South Korea and Peru, as well as with a consortium of researchers from European Union countries.
Alzheimer’s Disease Genetic Consortium (ADGC) is funded by a grant from the NIH’s National Institute on Aging, and conducts genome-wide association studies (GWAS) to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD). CADRE member Gerard Schellenberg, PhD, is the ADGC Principle Investigator.
Genome Center for Alzheimer’s Disease (GCAD) coordinates the compilation and quality control of all available Alzheimer’s Disease genomic data. GCAD is funded through the NIH/National Institute on Aging and is based at the University of Pennsylvania. It is led by CADRE member, Gerard Schellenberg, PhD.
The Genomics Core Laboratory for the Collaborative Health Initiative Research Program will handle genome sequencing for the CADRE initiative. The laboratory is part of the Collaborative Health Initiative Research Program, at the Uniformed Services University of the Health Sciences. The laboratory is led by CADRE member Clifton Delgard, PhD.
The National Alzheimer’s Coordinating Center (NACC) was established by the NIH’s National Institute on Aging to facilitate collaborative research. Using data collected from NIA-funded Alzheimer’s Disease Centers (ADCs) across the United States, NACC has developed and maintains a large relational database of standardized clinical and neuropathological research data.
The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) supports research focused on the etiology, early detection, and therapeutic development for Alzheimer disease and related dementias. NCRAD is funded by the NIH’s National Institutes on Aging (NIA). NCRAD stores clinical information and biological materials, such as DNA, plasma, serum, RNA, CSF, cell lines and brain tissue from individuals with Alzheimer’s disease and/or related dementias as well as healthy controls.
The National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) is a national genetics repository that facilitates access by qualified investigators to genotypic data. All data, findings and publications that come out of the CADRE work will be shared through NIAGADS to assure access. NIAGADS is based at the University of Pennsylvania, led by CADRE member, Li-San Wang, PhD.