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Coverage of CADRE members and our research.
This publication by Brian Kunkle, et al. in JAMA Neurology generated coverage in biomedical and general interest media.
Brian Kunkle, PhD, interviewed by the South Florida NBC affiliate
Brian Kunkle, PhD, interviewed by local TV news 10, South Florida
Summary and context from ALZFORUM
Christiane Reitz, MD, PhD, interviewed by the Columbia University Irving Medical Center media team
Kunkle et al. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis JAMA Neurol 2020
While African Americans are approximately twice as likely to develop Alzheimer’s disease than non-Hispanic whites (NHW), the largest Alzheimer’s disease GWAS to date have been conducted in NHW individuals. Though still small by GWAS standards, our current analysis of just over 8,000 individuals with African ancestry (2,784 AD cases; 5,222 controls) was able to identify 11 novel AD risk loci including one novel genome-wide significant locus near the gene IGF1R (P=1.7×10-9; MAF = 0.01), and 10 novel loci associated at P <= 5 x 10-7 (5 common variant loci and 6 rare variant loci). Interestingly, 8 of the 11 novel associated variants are not present in European ancestral populations according to the gnomAD allele frequency database.
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