Conference Abstracts
  CADRE investigators present their research on Alzheimer Disease and Related Dementias at numerous national and international conferences every year. We highlight the research presented annually at the Alzheimer’s Association International Conference (AAIC) and the American Society of Human Genetics (ASHG) meetings. Below we have provided lists of “CADRE-Related Abstracts” (i.e., CADRE investigator’s research on the whole genome sequence data from the ADSP) and “non-CADRE ADRD-Related Abstracts”. We provide this second list to help demonstrate the depth and breadth of ADRD-related research being performed by CADRE investigators. While the analysis of whole genome sequence data is the primary focus of CADRE, our investigators participate in many aspects of ADRD-related research.

Alzheimer’s Association International Conference 2023

AAIC Presentations

Featured Research Session:
The Alzheimer’s Disease Sequencing Project: Recent Advances and Update of Results
Chair: Margaret A. Pericak-Vance, PhD
Co-Chair: Li-San Wang, PhD

The Alzheimer Disease Sequencing Project: Enabling Discovery Through Diversity
Jonathan L. Haines, PhD

Multi-Ancestry Genetics for Alzheimer’s Disease: Alzheimer’s Disease Genetics Consortium
Gyungah R Jun, PhD

Functional genomic studies in diverse populations to characterize risk loci for Alzheimer Disease
Karen Nuytemans, PhD

ADSP Phenotype Harmonization Consortium
Timothy J. Hohman, PhD

Artificial Intelligence and Machine Learning (AIML) approaches to empower genomics, drug, and biomarker discovery in ADRD
Towfique Raj, PhD

Featured Research Session:
Alzheimer’s disease biomarkers in diverse populations
Tau and Amyloid Plasma Biomarker Analysis in Alzheimer’s Disease Cohorts from Diverse Genetic Ancestries
Anthony J. Griswold, Farid Rajabli, Catherine Garcia-Serje, Jamie Arvizu, Charles Golightly, Patrice L. Whitehead, Kara L. Hamilton-Nelson, Larry D. Adams, Katrina Celis, Jose Javier Sanchez, Sergio Tejada, Pedro R. Mena1, Takiyah Starks, Mario R Cornejo-Olivas, Maryenela Illanes-Manrique, Concepcion Silva, Michael L. Cuccaro, Jeffery M. Vance, Briseida E. Feliciano-Astacio, Goldie S. Byrd, Gary W. Beecham, Jonathan L. Haines, and Margaret A. Pericak-Vance

Featured Research Session: Global and equitable designs in aging research and subsequent research yields and the expansion of the field
Recruitment and Retention for Alzheimer’s Disease Diversity Genetic Cohorts in the Alzheimer’s Disease Sequencing Project (READD-ADSP)
Dr. Katalina McInerney Fernandez on behalf of HIHG and the READD-ADSP

Biomarker collection from the Caribbean Hispanic families from Dominican Republic and New York
Dolly Reyes-Dumeyer, BS1,2; Angel Piriz, MD3; Belisa Soriano, MD4; Yahaira Franco, MD5; Zoraida Dominguez Coronado, MD6; Patricia Recio, MD7; Diones Rivera Mejia, MD7,8; Martin Medrano, MD9; Rafael A. Lantigua, MD3; Badri N Vardarajan, MS, PhD10,11; Lawrence S. Honig, MD, PhD12 and Richard Mayeux, MD, MSc1,13,14,15,16

Featured Research Session: Novel GWAS Approaches in ADRD
Multi-Ancestry Genome-wide Association Analysis of Late-Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies Multiple Novel Cross-Ancestry Associations and Implicates Amyloid and Complement Pathways
Adam C. Naj, PhD1,2; Farid Rajabli, PhD3; Christiane Reitz, PhD, MD4,5; Gyungah R Jun, PhD6,7; Penelope Benchek, PhD8; Giuseppe Tosto, MD, PhD4,5; Jin Sha, MS2; Congcong Zhu, MS9; Nicholas A. Kushch10; Wan-Ping Lee, PhD11,12; Jacob Haut, BS13; Kara L. Hamilton-Nelson, MPH3; Nicholas R. Wheeler, PhD8; Yi Zhao, MS14; John Farrell, PhD7; Michelle Grunin, PhD8,15; Yuk Yee Leung, PhD11; Donghe Li, PhD7; Eder Lucio da Fonseca, PhD10; Jesse B. Mez, MD, MS9,16; Ellen L Palmer, PhD8; Jagan A. Pillai, MD, PhD17; Richard Sherva, PhD7; Yeunjoo E. Song8,15; Xiaoling Zhang, PhD9,18; Taha Iqbal, MS13; Omkar Pathak, MS14; Otto Valladares, MS11,12; Amanda B Kuzma, MS14; Brian W. Kunkle, PhD, MPH10,19; William S. Bush, PhD8,15; Li-San Wang, PhD11,12,20; Lindsay A. Farrer, PhD6,7,16,21,22; Jonathan L. Haines23,24; Richard Mayeux, MD, MSc25; Margaret A Pericak-Vance, PhD26; Gerald D. Schellenberg, PhD14,20 and Alzheimer’s Disease Genetics Consortium (ADGC)

Genome-wide association study for Alzheimer disease in APOE ɛ4/ɛ4 carriers
Samantha Clayton1; Daniel Goldstein, MS1; Li-San Wang, PhD2; Richard Mayeux, MD, MSc3; Jonathan L. Haines4; Margaret A. Pericak-Vance, PhD5; Gerald D. Schellenberg, PhD6; Kathryn L. Lunetta, PhD7; Rhoda Au, PhD1,7; Lindsay A. Farrer, PhD1,7; Thor D. Stein, MD, PhD1,8 and Gyungah R Jun, PhD1,7

Plenary Session: Novel GWAS Approaches in ADRD
Inclusion in research and clinical trials
Goldie S. Byrd, PhD, and Margaret A. A Pericak-Vance, PhD

 

AAIC CADRE-related Posters

A new risk locus on chromosome 1 is suggested by genome-wide association study in Peruvians for Alzheimer disease
B. Akgun, M. Cornejo-Olivas, N. Custodio, F. Rajabli, M. Soto-Añari, R. Montesinos, Z. Yang, B. C. Huaman, D. Reyes-Dumeyer, J. A. Cedeno, J. Rivero, P. R. Mena, L. D. Adams, P. G. Whitehead, K. L. Hamilton-Nelson, J. Rios-Pinto, A. Medina-Colque, C. L. Dalgard, R. Isasi, I, Cornejo-Herrera, M. Illanes-Manrique, E. Ochoa-Valle, E. Sarapura-Castro, K. Mejía, A. K. Milla-Neyra, S. Castro-Suarez; Alzheimer’s Disease Sequencing Project (ADSP); E. R. Martin1, A. Griswold, K. F. McInerney, M. L. Cuccaro, J. M. Vance, G.W. Beecham1, M.A. Pericak-Vance, G. Tosto7.

Identification of rare coding variants associated with Alzheimer’s disease.
Zainab Khurshid, John J. Farrell, Tong Tong, Congcong Zhu, Eden R. Martin, Margaret A. Pericak-Vance, Adam Naj, Amanda Kuzma, Laura Cantwell, Otto Valladares, Li-San Wang, Gerard Schellenberg, Jonathan L. Haines, Kathryn L. Lunetta, Yuk Yee Leung, Xiaoling Zhang, and Lindsay A. Farrer on behalf of the Alzheimer’s Disease Sequencing Project (ADSP)

Association of Common and Rare Variants with Alzheimer’s Disease in 16,905 individuals with Whole-Genome Sequence Data from the Alzheimer’s Disease Sequencing Project
Wan-Ping Lee, PhD; Seung Hoan Choi, PhD; Gerald D. Schellenberg, PhD; Anita L. DeStefano, PhD; Jonathan L. Haines; Gina M. Peloso, PhD and Collaboration on Alzheimer’s Disease Research (CADRE), and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)

A genome-wide association study in Puerto Ricans suggests new risk loci for Alzheimer disease
Farid Rajabli, PhD, Briseida E. Feliciano-Astacio, MD, Kara L. Hamilton-Nelson, MPH, Joe Rivero MS, Bilcag Akgun, MD, Larry D. Adams, MAS, Pedro Ramon Mena, MD, Sergio Tejada, MD1, Katrina Celis, MD, Jose Javier Sanchez, MD, Nereida I Feliciano, MD, Patrice L. Whitehead, BS, Michael Prough, MS, Parker Busse MD, Olivia Gardner, MD, PhD, Heriberto Acosta, MD, Angel Chinea, MD, The Alzheimer’s Disease Sequenching Project, Katalina McInerney, PhD, Jeffery M Vance, MD, PhD, Michael L Cuccaro, PhD, Gary W. Beecham, PhD and Margaret A. Pericak-Vance, PhD

Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimer’s Disease in individuals of African ancestry
Nicholas R. Ray, PhD1; Brian W. Kunkle, PhD, MPH; Kara L. Hamilton-Nelson, MPH; Jiji T. Kurup, MS; Mehmet I. Cosacak, PhD; Caghan Kizil, PhD; Melissa Jean-Francois, MPH; Michael L. Cuccaro; Jeffery M. Vance; Hugh C Hendrie, MB, ChB; Olusegun Baiyewu, MBBS; Adesola Ogunniyi, MD; Alzheimer’s Disease Genetics Consortium (ADGC); Eden R. Martin, PhD; Li-San Wang; Gary W. Beecham, PhD; Lindsay A. Farrer, PhD; Jonathan L. Haines; Goldie S. Byrd, PhD; Gerald D. Schellenberg, PhD; Richard Mayeux, MD, MSc1; Margaret A. Pericak-Vance and Christiane Reitz, PhD, MD

Association Between HSV-1 and Risk of Alzheimer’s Disease Detected by a Propensity-Score Matched Case Design
Marlene Tejeda, John Farrell1, Congcong Zhu, Lee Wetzler Kathryn L. Lunetta,
William S. Bush, Eden R. Martin, Li-San Wang, Gerard Schellenberg, Margaret A. Pericak-Vance, Jonathan L. Haines, Lindsay A. Farrer, and Richard Sherva

Blood-derived mitochondrial DNA copy number is associated with Alzheimer’s Disease through the regulation of plasma lipid and amino acid metabolism
Tong Tong, MS; Congcong Zhu, MS; John Farrell, PhD; Zainab Khurshid, MS; Eden R. Martin, PhD; Margaret A. Pericak-Vance, PhD; Li-San Wang, PhD; Gerald D. Schellenberg, PhD; Jonathan L. Haines; Kathryn L. Lunetta, PhD; Lindsay A. Farrer, PhD; and Xiaoling Zhang, PhD

Genetic predictors of multiple cognitive domains within ancestry groups in older adults
Skylar Walters, MS; Jaclyn M. Eissman, BS; Shubhabrata Mukherjee, PhD, MS; Michael L. Lee, PhD, MPH; Seo-Eun Choi, PhD; Phoebe Scollard, MA; Emily H. Trittschuh, PhD; Jesse B. Mez, MD, MS; William S. Bush, PhD8; Brian W. Kunkle, MPH, PhD9; Adam C. Naj, PhD10,11; Katherine A. Gifford, PsyD; Michael L. Cuccaro; Carlos Cruchaga, PhD; Margaret A Pericak-Vance, PhD; Lindsay A. Farrer, PhD; Li-San Wang, PhD; Jonathan L. Haines; Angela L. Jefferson, PhD; Walter A. Kukull, PhD; C Dirk Keene, MD, PhD; Andrew J. Saykin, PsyD; Paul M Thompson, PhD; Eden R. Martin, PhD; David A. A Bennett, MD; Lisa L. Barnes, PhD; Julie A Schneider, MD; Paul K Crane, MD, MPH; Marilyn S. Albert, PhD; Sterling C Johnson, PhD; Corinne D. Engelman, MSPH, PhD; Richard Mayeux, MD, MSc; Badri N Vardarajan, MS, PhD; Timothy J. Hohman, PhD; Logan C Dumitrescu, PhD, MS and The Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC); The Alzheimer’s Disease Sequencing Project (ADSP)

 

CADRE Investigator Other ADRD-related research Posters

Association between known Alzheimer’s disease risk loci and in vivo brain amyloid pathology in a Korean Cohort
Hyejin Ahn, MA1; Min Soo Byun, MD, PhD2,3,4; Dahyun Yi, PhD5; Gijung Jung, RN, PhD5; Yen-Ning Huang6,7; Anthony J. Griswold, PhD8; Margaret A. A Pericak-Vance, PhD8; Yu Kyeong Kim, MD, PhD9; Yun-Sang Lee, PhD10; Chul-Ho Sohn, MD, PhD11; Koung Mi Kang, MD11; Jun-Young Lee, MD, PhD2,12; Andrew J. Saykin, PsyD6,13,14; Kwangsik Nho, PhD6,7,15 and Dong Young Lee, MD, PhD1,2,3,4,5

Digital is the New Blood: Enabling the Present and the Future
Rhoda Au, PhD1,2,3,4,5,6,7,8; Zachary T Popp5; Spencer Low, BS5; Phillip H Hwang, PhD, MPH9,10; Ileana De Anda-Duran, MD, MPH11; Stephanie Li, MA5; Salman Rahman5; Huitong Ding, PhD5; Akwaugo Igwe5; Cody Karjadi, MS5,9; Ting Fang Alvin Ang, MD, MPH8,9,12; Sherral A. Devine, PhD8,9; Ashita S Gurnani, PhD13; Jesse B. Mez, MD, MS5,6,7,9; Lindsay A. Farrer, PhD5,9,14,15; Preeti Sunderaraman, PhD9,16; Honghuang Lin, PhD17,18 and Vijaya B. Kolachalama, PhD18,19,20,21,22,23

Association of APOE with Alzheimer’s disease in Mexico, Caribbean-Hispanics, Peruvian and Mexican Americans
Sandra Barral, PhD1; Miguel Arce Rentería, PhD2; Dolly Reyes-Dumeyer, BS3; Silvia Mejia Arango, PhD4; Alejandra Michaels Obregon, MS5; Rafael Samper-Ternent, MD, PhD6; Rebeca Wong, PhD6; Robert Barber, PhD7; Nicole Phillips, PhD8; Sid E. O’Bryant, PhD9; Rosa Montesinos, MD10; Marcio F. Soto-Añari, PhD11; Nilton Custodio, MD, PhD12 and Giuseppe Tosto, MD, PhD13

X-chromosome wide association study for Alzheimer’s disease
Celine Bellenguez, Lissette Gomez, Brian Kunkle, Julie Le Borgne

Machine-learning based classification of Frontotemporal dementia in electronic health records for genetic discovery
Jennifer E. Below, PhD1; Douglas Shaw, BS2; Grahame Evans, BS2; James T Baker, BS2; Ryan J Bohlender, PhD3; Alex Petty, BS4; Lauren E Petty, PhD2; Rashedeh Roshani, MS5; Jonathan Lifferth, BS2; Lisa Bastarache, MS2; Adam C. Naj, PhD6; William S. Bush, PhD7; Ryan Darby, MD2; Corey T McMillan, PhD8; David Samuels, PhD9 and Chad D Huff, PhD3

Functional investigation of the gliovascular niche-related genes and their relevance to Alzheimer’s disease pathomechanisms in zebrafish
Prabesh Bhattarai, PhD1,2; Mehmet I. Cosacak, PhD3; Annie J Lee, PhD2,4; Elanur Yilmaz, PhD5; Ozkan Is, PhD6; Xue Wang, PhD6; Badri N Vardarajan, MS, PhD7,8,9; Nilufer Ertekin-Taner, MD, PhD6; Richard Mayeux, MD, MSc10,11,12,13 and Caghan Kizil, PhD1,2

The Black Experience of COVID-19. What is next for Clinical Psychologists in Alzheimer’s Disease research post-pandemic?
Laurel Y Browne, BA, MA1; Jeffrey A Cedeno, BA, MA1; Payton Gabrielle White, BS2; Oliver Cesar, BA3; Dishari Zaman Azad, BA4; Giuseppe Tosto, MD, PhD5,6; Ricardo S Osorio, MD7,8 and Omonigho Michael M Bubu, MD, MPH, PhD9

Assessing the functional effect of the Presenilin-1 G206A variant on age of onset of Alzheimer Disease in the Puerto Rican population
K. Celis, F. Rajabli, A. Griswold, L.D Adams, S. Tejada, J.J Sanchez, S. Simon, K. Hamilton-Nelson, N.R Gomez, P. Whitehead, P. Mena, S. Slifer, J. Arvizu, C.G Golightly, C. Silva, H. Acosta, M.L Cuccaro, J.M Vance, G.W Beecham, B. Feliciano-Astacio, D. Dykxhoorn, J. Young, M.A Pericak-Vance.

The Prediction of Alzheimer’s Disease through Multi-Trait Genetic Modeling
Kaylyn Clark, BS1; Wei Fu, PhD1; Chia-Lun Liu, PhD1; Pei-Chuan Ho, PhD1; Hui Wang, PhD1; Wan-Ping Lee, PhD1; Shin-Yi Chou, PhD2; Li-San Wang, PhD1 and Jung-Ying Tzeng3

Genome-wide association study for Alzheimer disease in APOE ɛ4/ɛ4 carriers
Samantha Clayton1; Daniel Goldstein, MS1; Li-San Wang, PhD2; Richard Mayeux, MD, MSc3; Jonathan L. Haines4; Margaret A. Pericak-Vance, PhD5; Gerald D. Schellenberg, PhD6; Kathryn L. Lunetta, PhD7; Rhoda Au, PhD1,7; Lindsay A. Farrer, PhD1,7; Thor D. Stein, MD, PhD1,8 and Gyungah R Jun, PhD1,7

Genetic Associations with Age at Dementia Onset in the PSEN1 E280A Colombian Kindred
J. Nicholas Cochran, PhD1; Juliana Acosta-Uribe, MD2,3; Bianca T Esposito, PhD4; Lucia Madrigal, PhD3; David Aguillon, MD5; Margarita M. Giraldo-Chica, MD3; Jared W Taylor1; Joseph Bradley6; Brian Fulton-Howard, PhD4; Shea J Andrews, PhD4; Natalia Acosta-Baena, MD, MSc3; Diana Alzate, BA3; Gloria Garcia, MS3; Francisco Piedrahita3; Hugo Lopez3; Ashlyn G Anderson, MS1; Ivan Rodriguez-Nunez, PhD1; Kevin Roberts1; Devin Absher, PhD1; Richard M. Myers, PhD1; Gary W. Beecham, PhD7; Christiane Reitz, PhD, MD8; Lindsay F. Rizzardi, PhD1; Maria Victoria Fernandez, PhD6; Alison Goate, PhD4; Carlos Cruchaga, PhD9; Alan E. Renton, PhD4; Francisco Lopera, MD5; Kenneth S. Kosik, MD2 and Dominantly Inherited Alzheimer Network

APOE4-stratified GWAS across cognitive domains in non-Hispanic white and non-Hispanic black individuals
Alex G Contreras, BS1; Skylar Walters, MS2; Shubhabrata Mukherjee, PhD3; Michael L. Lee, PhD, MPH3; Seo-Eun Choi, PhD3; Phoebe Scollard, MA3; Emily H Trittschuh, PhD3; Jesse B. Mez, MD, MS4; William S. Bush, PhD5; Corinne D. Engelman, MSPH, PhD6; Qiongshi Lu, PhD7; David W. Fardo, PhD8; Keith F. Widaman, PhD9; Rachel Buckley, PhD10; Elizabeth C. Mormino11; Brian W. Kunkle, PhD, MPH12; Adam C. Naj, PhD13; Lindsay R. Clark, PhD14; Katherine A. Gifford, PsyD15; The Alzhemer’s Disease Neuroimaging Initiative (ADNI)16; Alzheimer’s Disease Genetics Consortium17; The Alzheimer’s Disease Sequencing Project (ADSP)18; Michael L. Cuccaro12; Carlos Cruchaga, PhD19; Margaret A. Pericak-Vance12; Lindsay A. Farrer, PhD20; Li-San Wang, PhD13; Gerald D. Schellenberg, PhD13; Jonathan L. Haines21; Angela L. Jefferson, PhD15; Sterling C Johnson, PhD14; Walter A. Kukull, PhD3; Marilyn S. Albert, PhD22; C Dirk Keene, MD, PhD3; Andrew J. Saykin, PsyD23; Eric B Larson, MD, MPH3; Reisa A. Sperling, MD24; Richard Mayeux, MD, MSc25; Paul M Thompson, PhD26; Eden R. Martin, PhD27; David A. A Bennett, MD28; Lisa L. Barnes, PhD29; Julie A Schneider, MD30; Paul K Crane, MD, MPH3; Logan C Dumitrescu, PhD, MS15,31 and Timothy J. Hohman, PhD2,15

A risk variant in TTC3 modifies the actin cytoskeleton organization and PI3K-Akt signaling in iPSC-derived forebrain neurons
Holly N. Cukier, Carolina L. Duarte, Mayra Juliana Laverde-Paz, Shaina A. Simon, Derek J. Van Booven, Amanda T. Miyares, Jeffery M. Vance, Margaret A. Pericak-Vance, Anthony J. Griswold, Derek M. Dykxhoorn

RNA-seq study on the effect of MAPT rs242557 deletion in HMC3 cells
Rueben Das, PhD1; Pavel P. Kuska, PhD2; Wan-Ping Lee, PhD1; Eirene Choi1; Ming Jiang1; Beth A. Dombroski, PhD1 and Gerald D. Schellenberg, PhD1

Uncovering the Role of an ABCA7 Frameshift Deletion in African American Alzheimer’s Disease Cellular Pathology
Brooke A. DeRosa, Younji Nam, Charles G. Golightly, Shaina A. Simon, Jamie Arvizu, Larry D. Adams, Takiyah D. Starks, Juliana Laverde-Paz, Holly N. Cukier, Jeffery M. Vance, Michael L. Cuccaro, Jonathan L. Haines, Goldie S. Byrd, Gary W. Beecham, Margaret A. Pericak-Vance, Derek M. Dykxhoorn

Genetic architecture of multiple domains of cognition among SuperAgers
Alaina Durant, BS1; Shubhabrata Mukherjee, PhD, MS2; Michael L. Lee, PhD, MPH2; Seo-Eun Choi, PhD2; Phoebe Scollard, MA2; Emily H. Trittschuh, PhD3,4; Jesse B. Mez, MD, MS5; William S. Bush, PhD6; Brian W. Kunkle, PhD, MPH7; Adam C. Naj, PhD8,9; Katherine A. Gifford, PsyD1; Michael L. Cuccaro7; Carlos Cruchaga, PhD10,11; Jason J. Hassenstab, PhD12; Margaret A. Pericak-Vance7; Lindsay A. Farrer, PhD5,13,14; Li-San Wang, PhD9; Jonathan L. Haines6; Angela L. Jefferson, PhD1; Walter A. Kukull, PhD15; C Dirk Keene, MD, PhD16; Andrew J. Saykin, PsyD17,18; Paul M Thompson, PhD19; Eden R. Martin, PhD20; David A. A Bennett, MD21; Lisa L. Barnes, PhD21; Julie A Schneider, MD21; Paul K Crane, MD, MPH2; Marilyn S. Albert, PhD22; Sterling C Johnson, PhD23,24; Corinne D. Engelman, MSPH, PhD24,25,26; Richard Mayeux, MD, MSc27; Badri N Vardarajan, MS, PhD27; Logan C Dumitrescu, PhD, MS28,29; Timothy J. Hohman, PhD1,29

Sex-specific genetic architecture of multiple domains of cognition among older adults
Jaclyn M. Eissman, BS1,2; Skylar Walters, MS1,2; Shubhabrata Mukherjee, PhD, MS3; Michael L. Lee, PhD, MPH3; Seo-Eun Choi, PhD3; Phoebe Scollard, MA3; Emily H. Trittschuh, PhD4,5; Jesse B. Mez, MD, MS6; William S. Bush, PhD7; Brian W. Kunkle, PhD, MPH8; Adam C. Naj, PhD9,10; Katherine A. Gifford, PsyD1; Alzheimer’s Disease Neuroimaging Initiative11; The Alzheimer’s Disease Sequencing Project (ADSP)12; Alzheimer’s Disease Genetics Consortium (ADGC)12; Michael L. Cuccaro8; Carlos Cruchaga, PhD13,14; Margaret A Pericak-Vance, PhD8; Lindsay A. Farrer, PhD6,15,16; Li-San Wang, PhD17; Jonathan L. Haines7; Angela L. Jefferson, PhD1; Walter A. Kukull, PhD18; C Dirk Keene, MD, PhD19; Andrew J. Saykin, PsyD20,21; Paul M Thompson, PhD22; Eden R. Martin, PhD8; David A. A Bennett, MD23; Lisa L. Barnes, PhD23; Julie A Schneider, MD23; Marilyn S. Albert, PhD24; Sterling C Johnson, PhD25,26; Corinne D Engelman, PhD, MSPH26,27,28; Richard Mayeux, MD, MSc29; Badri N Vardarajan, MS, PhD29; Paul K Crane, MD, MPH3; Timothy J. Hohman, PhD1,2 and Logan C Dumitrescu, PhD, MS1,2

Recruitment and Retention in the Puerto Rico Alzheimer’s Disease Initiative
Briseida E. Feliciano-Astacio, MD, Farid Rajabli, Ph, Michael B. Prough, Kara L. Hamilton-Nelson, MPH, Larry D. Adams, Pedro R. Mena, MD, Sergio J. Tejada, MD, Jose Javier Sanchez, MD, MS,Katrina Celis, MD, Concepcion Silva-Vergara, MBA, Patrice G. Whitehead, BS, Heriberto Acosta, MD,Nereida I Feliciano, MD, Angel Chinea, Katalina McInerney, PhD, Jeffery M. Vance, Michael L.Cuccaro, Gary W. Beecham, PhD and Margaret A. Pericak-Vance

Impact of sex, age, and ancestry on Apolipoprotein E (APOE) risk for Alzheimer’s disease (AD)
Omar Garcia-Rodriguez, PhD, Lily Wang PhD, Juan Young PhD, Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC), Eden Martin PhD1, & Brian Kunkle PhD

Cerebral amyloid angiopathy and neuritic plaques impact tangle burden and cognitive decline in a heterogeneous clinical population
Dana Godrich1; Jeremy Pasteris2; Eden R. Martin, PhD1,2; Gerald D. Schellenberg, PhD3; Margaret A. Pericak-Vance1,4; Michael L. Cuccaro1,2; William K. Scott1,2; Tatjana Rundek, MD PhD5; Walter A. Kukull, PhD6; Thomas J. Montine, MD, PhD7 and Gary W. Beecham, PhD1,2

GWAS identifies genetic factors associated with severity of cerebral amyloid angiopathy pathology
Dana Godrich, Jeremy Pasteris, Eden R. Martin, Gerard Schellenberg, Margaret A. Pericak-Vance, Michael Cuccaro, William K. Scott, Walter Kukull, Thomas Montine, Gary W. Beecham, and the Alzheimer Disease Genetics Consortium.

Proteome Analysis in Plasma and Brain Reveals a Novel Plasma Biomarker Linked to Antemortem Cognitive Impairment and Postmortem Neuropathological Traits for Alzheimer Disease
Daniel Goldstein, MS1; Nurgul Aytan, PhD1; Joseph N Palmisano, MPH, MA2; Yorghos Tripodis, PhD3; Katherine W Turk, MD4; Maureen K. O’Connor, PsyD4; Lee E Goldstein, MD, PhD5; Andrew E Budson, MD6; Wei Qiao Qiu, M.D., Ph.D4; Neil W Kowall, MD7; Ann C. McKee, MD8; Jesse B. Mez, MD, MS9; Michael L Alosco, PhD8; Lindsay A. Farrer, PhD10; Thor D. Stein, MD, PhD11; Gyungah R Jun, PhD2 and Boston University Alzheimer’s Disease Research Center

The NIA Genetics of Alzheimer’s Disease Data Storage Site API: a toolkit for exploring Alzheimer’s disease genetics and genomic annotations
Emily Greenfest-Allen, PhD1,2; Pavel P. Kuska, PhD3; Wan-Ping Lee, PhD1,4; Yuk Yee Leung, PhD1,4; Otto Valladares, MS1,4 and Li-San Wang, PhD1,4,5

Multi-cohort genome-wide association study on flortaucipir PET identifies novel risk loci associated with tau deposition and its role in AD pathology
Tamil Iniyan Gunasekaran, PhD1; Annie J Lee, PhD2,3,4; Logan C Dumitrescu, PhD, MS5,6; Elizabeth C. Mormino7; Reisa A. Sperling, MD8,9; Andrew J. Saykin, PsyD10,11; Timothy J. Hohman, PhD5,6; Badri N Vardarajan, MS, PhD1,3,4 and Alzheimer’s Disease Neuroimaging Initiative

MAPT subhaplotypes and chronic traumatic encephalopathy
Xudong Han, MS1; Jillian Petrosky1; Sarah Bald1; Yichi Zhang1; Richard Sherva, PhD2; Jaeyoon Chung, PhD3; Bobak Abdolmohammadi, BA4; Shruti Durape, MD, MPH5,6; Brett M Martin, MS7,8; Joseph N Palmisano, MPH, MA7,9; Kurt W. Farrell, PhD10,11; John Farrell, PhD2; Jonathan D Cherry, PhD12,13,14; Victor E. Alvarez, MD13,14,15,16,17; Bertrand R. Huber, MD, PhD4,5,7,14,17; Michael L Alosco, PhD4,7; Yorghos Tripodis, PhD4,18; Robert A Stern, PhD15; Thor D. Stein, MD, PhD7,19,20; Lindsay A. Farrer, PhD2,5,7; John F. Crary, MD PhD10,11; Ann C. McKee, MD4,7,14,20 and Jesse B. Mez, MD, MS5,7,15

Alzheimer’s disease genetics and real-world patient data fuel target and drug discovery in European and African American ancestries
Yuan Hou, PhD1; Pengyue Zhang, PhD2; Fan Fan3; Lynn M. Bekris, PhD4; Jonathan L. Haines5; Andrew A. Pieper, PhD, MD6; Bruce D. Hammock, PhD7; James B Leverenz, MD1; Jeffrey L. Cummings, MD, ScD8 and Feixiong Cheng, PhD1

Impact of COVID-19 in cognitively unimpaired individuals and dementia caregivers from the Peruvian Alzheimer Disease Initiative (PeADI)
Maryenela Illanes-Manrique, MD Pedro Ramon Mena, Diana Cubas-Montecino, BS, Larry D. Adams, Elison Sarapura-Castro, MD, Sheila Castro-Suare MD, Julia Rios-Pinto, MS, Koni K. Mejía, MD, Angel Medina-Colque, PhD, Gary W. Beecham, PhD, Ivan Cornejo-Herrera, MD, Jeffery M. Vance, EdwardOchoa-Valle, MD, Michael L. Cuccaro, Mario Cornejo-Olivas, MD and Margaret A. Pericak-Vance

Gliovascular molecular alterations in Alzheimer’s disease: a cross-tissue, cross-species study
Ozkan Is, PhD1; Xue Wang, PhD1; Joseph S. Reddy, PhD1; Tulsi Patel, PhD1; Yuhao Min, BS1; Zachary Quicksall, MS1; Michael G. Heckman, MS1; Junli Gao, PhD1; Jeremiah Bergman, BS1; Sandro Gabriel (Sandro Da Mesquita) Ferreira Da Mesquita, PhD1; Caghan Kizil, PhD2,3; Prabesh Bhattarai, PhD2,3; Mehmet I. Cosacak, PhD4; Annie J Lee, PhD3,5; Badri N Vardarajan, MS, PhD6; Richard Mayeux, MD, MSc3,6,7; Shunsuke Koga, MD, PhD1; Takahisa Kanekiyo, MD, PhD1; Launia J White1; Naomi Kouri, PhD8; Kaancan Deniz, MD1; Frederick Q Tutor-New, BA, BS1; Troy Carnwath, BS1; Stephanie R Oatman, BS1; Laura Lewis-Tuffin, PhD1; Thuy Nguyen, BS1; Minerva M. Carrasquillo, PhD1; Jonathan Graff Radford, MD9; Ronald C. Petersen, MD, PhD9; Clifford R. Jack Jr., MD9; Kejal Kantarci, MD, MS10; Kwangsik Nho, PhD11,12; Andrew J. Saykin, PsyD13,14; Dennis W. Dickson, MD1; Melissa E. Murray, PhD1; Mariet Allen, PhD1 and Nilufer Ertekin-Taner, MD, PhD1

Predicted gene expression identifies novel tissue-specific gene predictors of memory performance in older adults
Vaibhav A Janve, PhD1,2; Derek B Archer, PhD1,2; Jaclyn M. Eissman, BS1,2; Alaina Durant, BS2; Shubhabrata Mukherjee, PhD, MS3; Michael L. Lee, PhD, MPH4; Seo-Eun Choi, PhD4; Phoebe Scollard, MA4; Emily H. Trittschuh, PhD5,6; Jesse B. Mez, MD, MS7; William S. Bush, PhD8; Corinne D Engelman, PhD, MSPH9; Qiongshi Lu, PhD10,11; David W. Fardo, PhD12,13; Rachel F. Buckley, PhD14,15,16; Elizabeth C. Mormino17; Brian W. Kunkle, PhD, MPH18; Adam C. Naj, PhD19,20; Katherine A. Gifford, PsyD2; Michael L. Cuccaro18; Carlos Cruchaga, PhD21; Margaret A. Pericak-Vance, PhD18; Lindsay A. Farrer, PhD22,23,24; Li-San Wang, PhD25; Gerald D. Schellenberg, PhD20; Jonathan L. Haines26; Angela L. Jefferson, PhD2; Walter A. Kukull, PhD3; Marilyn S. Albert, PhD27; C Dirk Keene, MD, PhD28; Andrew J. Saykin, PsyD29; Reisa A. Sperling, MD30; Richard Mayeux, MD, MSc31,32,33; Paul M Thompson, PhD34; Eden R. Martin, PhD35; David A. A Bennett, MD36; Lisa L. Barnes, PhD36; Julie A Schneider, MD36; Logan C Dumitrescu, PhD, MS1,2; Paul K Crane, MD, MPH37; Timothy J. Hohman, PhD1,2 and Alzheimer’s Disease Neuroimaging Initiative (ADNI),• Alzheimer’s Disease Genetics Consortium (ADGC),• Alzheimer’s Disease Sequencing Project (ADSP)

Microglia from individuals with mild cognitive impairment (MCI) and AD show differences in transcriptional burst kinetics
Bowen Jin1, Margaret A. Pericak-Vance, Eden R. Martin, Lindsay Farrer, Jonathan L. Haines, William S. Bush2*

Network-based Genetic Subtyping for Target Prioritization and Drug Repositioning: The Artificial Intelligence for Alzheimer’s Disease (AI4AD) Consortium
Gyungah R Jun

Association of Polygenic Risk Score of Alzheimer’s disease with A/T/N Biomarkers and Cognitive Decline
Joon Hyung Jung, MD1,2; Min Soo Byun, MD, PhD1,3; Dahyun Yi, PhD4; Gijung Jung, RN, PhD3; Hyejin Ahn, MA5; Shiwei Liu, PhD6; Yen-Ning Huang6; Anthony J. Griswold, PhD7; Margaret A. A Pericak-Vance, PhD7; Yu Kyeong Kim, MD, PhD8; Yun-Sang Lee, PhD1; Chul-Ho Sohn, MD, PhD1,3; Koung Mi Kang, MD3; Jun-Young Lee, MD, PhD1,8; Andrew J. Saykin, PsyD6; Kwangsik Nho, PhD6 and Dong Young Lee, MD, PhD1,3,4,5

Metabolites correlate with plasma biomarkers and clinical diagnosis of Alzheimer’s Disease
Vrinda Kalia, PhD1; Dolly Reyes-Dumeyer, BS1; Saurabh Dubey1; Renu Nandakumar, PhD1; Annie J Lee, PhD1; Rafael A. Lantigua, MD1; Martin Medrano, MD2; Diones Rivera Mejia, MD3,4; Patricia Recio, MD3; Lawrence S. Honig, MD, PhD5; Richard Mayeux, MD, MSc1; Gary W Miller, PhD1 and Badri N Vardarajan, MS, PhD1

A Genome-Wide Search for Pleiotropy in More Than 100,000 Harmonized Longitudinal Cognitive Domain Scores
Moonil Kang, Ting Fang Alvin Ang2,3,4, Sherral A. Devine2,3, Richard M. Sherva1, Shubhabrata Mukherjee5, Emily H. Trittschuh6,7, Laura E. Gibbons5, Phoebe Scollard5, Michael Lee5, Seo-Eun Choi5, Brandon Klinedinst5, Connie Nakano5, Logan C. Dumitrescu8,9, Timothy J. Hohman8,9, Michael L. Cuccaro10, Andrew J. Saykin11,12,13, Walter A. Kukull14, David A. Bennett15, Li-San Wang16, Richard P. Mayeux17, Jonathan L. Haines18, Margaret A. Pericak-Vance10, Gerard D. Schellenberg16, Paul K. Crane5, Rhoda Au2,3,4,19,20, Kathryn L. Lunetta3,21, Jesse B. Mez3,19,22*, and Lindsay A. Farrer

Multi-ethnic genome-wide, gene-based study identifies genes that interact with vascular risk factors in Alzheimer’s Disease (AD)
Annie J Lee, PhD1,2,3; Dolly Reyes-Dumeyer, BS1,2,3; Philip L De Jager, MD, PhD1,4; David A. A Bennett, MD5; Julie A Schneider, MD6; Vilas Menon, PhD1,7; Yanling Wang, MD, PhD5; Rafael A. Lantigua, MD8; Martin Medrano, MD9; Diones Rivera Mejia, MD10; Ivonne Z. Jiménez-Velázquez, MD11; Walter A. Kukull, PhD12; Adam M. Brickman, PhD3; Jennifer J. Manly, PhD1,3; Giuseppe Tosto, MD, PhD1,2,3; Caghan Kizil, PhD1,3; Lindsay A. Farrer, PhD13; Jesse B. Mez, MD, MS14; Jaeyoon Chung15; Badri N Vardarajan, MS, PhD1,2,3 and Richard Mayeux, MD, MSc16

Interaction of genetic and cardiovascular risk factors identifies pathways involved in Alzheimer’s Disease
Annie J Lee, PhD1,2; Neha S Raghavan, PhD3,4,5; Prabesh Bhattarai, PhD1,6; Dolly Reyes-Dumeyer, BS7,8; Philip L De Jager, MD, PhD9; David A. A Bennett, MD10; Julie A Schneider, MD11; Vilas Menon, PhD12; Yanling Wang, MD, PhD10; Rafael A Lantigua, MD1; Martin Medrano, MD13; Diones Rivera Mejia, MD14; Ivonne Z. Jiménez-Velázquez, MD15,16; Walter A. Kukull, PhD17,18,19,20; Adam M. Brickman, PhD7,21,22,23,24; Jennifer J. Manly, PhD1,7,23,25; Giuseppe Tosto, MD, PhD1,8,26,27; Richard Mayeux, MD, MSc1,5,7,8,22,28; Caghan Kizil, PhD1,6 and Badri N Vardarajan, PhD4

ADSP Whole Genome Sequencing (WGS) Release 4 Data Update from Genome Center for Alzheimer’s Disease
Yuk Yee Leung, PhD1,2; Wan-Ping Lee, PhD2; Amanda B Kuzma, MS3; Prabhakaran Gangadharan, MS4; Heather Issen, MS5; Liming Qu, MS4; Youli Ren, MS6; Laura B Cantwell7; Otto Valladares, MS2; Yi Zhao, MS3; Taha Iqbal, MS8; Michael A. Schmidt, PhD9; Pedro R. Mena, MD9; Badri N Vardarajan, MS, PhD10; Clifton L. Dalgard, PhD, CLS11; Brian W. Kunkle, PhD, MPH12; William S. Bush, PhD13; Eden R. Martin, PhD12; Adam C. Naj, PhD14; Jonathan L. Haines15; Margaret A. Pericak-Vance16; Li-San Wang, PhD2; Gerald D. Schellenberg, PhD17 and the Alzheimer’s Disease Sequencing Project (ADSP)

Investigating drug repurposing for the prevention of Alzheimer’s disease and related dementias using electronic health records in the University of Pennsylvania Health System
Lu Li, BA1; Qiong Wu, PhD1; Sori Kim Lundin, BS2; Adam C. Naj, PhD1; Ruben C Gur, PhD1; Katya Rascovsky, PhD1; David A. Wolk, MD1; Cui Tao, PhD2 and Yong Chen, PhD1

The Genetics of Cognitive Resistance and Resilience in the Ohio and Indiana Amish
Leighanne R Main1,2, Yeunjoo E Song1,2, Renee A Laux1, Kristy L Miskimen1, Michael L Cuccaro3, Paula K Ogrocki4,5, Alan J Lerner4,5, Jeffery M Vance3, M Denise Fuzzell1, Sarada L Fuzzell1, Sherri D Hochstetler3, Michael D Osterman1,2, Audrey Lynn1, Daniel A Dorfsman3, Laura J Caywood3, Michael B Prough3, Larry D Adams3, Jason E Clouse3, Sharlene D Herington3, William K Scott3, Margaret A Pericak-Vance3 and Jonathan L Haines1,2

MCI in Caribbean Hispanics shows increased impairment in attention and working memory domains relative to non-Hispanic White individuals
Katalina F. McInerney, PhD, Andrew F. Zaman, PhD1, Pedro Ramon Mena, MD1, Larry D. Adams, MAS, Sergio Tejada, MD1, Jose Javier Sanchez, MD, Katrina Celis, MD1, Kara L. Hamilton-Nelson, MPH, Briseida E. Feliciano-Astacio, MD, Farid Rajabli, PhD, Gary W. Beecham, PhD, Jeffery M. Vance, MD, PhD, Michael L. Cuccar, Margaret A. Pericak-Vance, PhD

Effects of structural and social determinants of health and comorbidities on ethno-racial differences in ATN plasma biomarkers of Alzheimer’s disease: A HABS-HD study
Karin L. Meeker, PhD1; Beau Ances, MD, PhD2; Melissa Petersen, PhD3; Robert Barber, PhD4; Kristine Yaffe, MD5; Zhengyang Zhou, PhD3; Jorge J Llibre-Guerra, MD1; Fan Zhang, PhD3; James Hall, PhD3; Amy J. Kind, MD, PhD6; Joseph H. Lee, DrPH7; Badri N Vardarajan, PhD8; Annie Cohen, PhD9; Michelle M. Mielke, PhD10; Mark Mapstone, PhD11; Ganesh M. Babulal, OTD, PhD12 and Sid E. O’Bryant, PhD3

The Alzheimer’s Disease Sequencing Project – Follow Up Study (ADSP-FUS): APOE genotype status and demographic characteristics across datasets.
Pedro Ramon Mena, MD, Andrew Zaman, PhD, MPH, Kelley M. Faber, MS, Larry D. Adams, MAS, Jovita Inciute, MS, Patrice Whitehead, B.S., Tatiana M. Foroud, PhD, Dolly Reyes-Dumeyer, B.S, Amanda B Kuzma, MS, Heather Issen, BS, MS, Adam Naj, PhD, Eden R. Martin, PhD, Clifton L. Dalgard, PhD, CLS, Gerard D Schellenberg, PhD, Li-San Wang, PhD, Richard Mayeux, MD, Badri N Vardarajan, PhD Jeffery M. Vance, MD, PhD, Michael L. Cuccaro, PhD, Brian W. Kunkle, PhD, MPH, and Margaret A. Pericak-Vance, PhD1

Improving gene expression prediction models through the use of meta-analysis summary statistics
Makaela Mews, BS, Adam C. Naj, PhD, Jennifer E. Below, PhD, and William S. Bush, PhD

Exposomics for Characterization of Environmental Drivers of AD
Gary W Miller, PhD1; Vrinda Kalia, PhD1; Yunjia Lai, PhD2; Lawrence S. Honig, MD, PhD3; Richard Mayeux, MD, MSc4; Badri N Vardarajan, MS, PhD5; Rafael A. Lantigua, MD1; Annie J Lee, PhD1; Jennifer J. Manly, PhD1,6 and Renu Nandakumar, PhD1

Identifying Optimal Blood Tau Epitopes for the Detection of Alzheimer’s Disease Neuropathology: An Immunoprecipitation Mass Spectrometry and Autopsy Study
Laia Montoliu-Gaya, PhD1; Michael L Alosco, PhD2; Eukyung Yhang, BA3; Yorghos Tripodis, PhD4; Nicholas J. Ashton, PhD5; Juan Lantero Rodriguez, PhD6; Hugo J Aparicio, MD, MPH7; Michael A Sugarman, PhD8; Madeline Ally8; Brett M Martin, MS2; Joseph N Palmisano, MPH, MA3; Eric Steinberg, MSN8; Irene Simkin, MS8; Katherine W Turk, MD7; Andrew E Budson, MD7; Rhoda Au, PhD2; Lindsay A. Farrer, PhD9; Gyungah R Jun, PhD10; Neil W Kowall, MD11; Robert A Stern, PhD11; Ronald J Killiany, PhD8; Lee E Goldstein, MD, PhD11; Wei Qiao Qiu, M.D., Ph.D7; Bertrand R. Huber, MD, PhD12; Jesse B. Mez, MD, MS11; Ann C. McKee, MD12; Henrik Zetterberg, MD, PhD13; Johan Gobom, PhD6 and Thor D. Stein, MD, PhD11

APOE genotype vs Local ancestry: what contributes the most to Alzheimer’s disease risk?
S. Moura, K. Celis, M. Munis, F. Rajabli, J. Rivero, K. Hamilton-Nelson, P. Whitehead, M. Gearing, D. Bennett, M. Flanagan, S. Weintraub, C. Geula, W. Scott, T. Schuck, F. Jin, D. Dykxhoorn, M. Pericak-Vance, A. Griswold, J. Young, J. Vance.

The genomic regulatory architecture of frontal cortex of Amerindian and African ancestries for functional studies of Alzheimer’s disease.
S. Moura, K. Celis, M. Munis, L. Wang, W. Xu, F. Rajabli, J. Rivero, K. Hamilton-Nelson, P. Whitehead, M. Gearing, D. Bennett, M. Flanagan, S. Weintraub, C. Geula, W. Scott, T. Schuck, R. Rissman, S. Wright, J. Silva, B. Gawronski, E. Monuki, E. Head, W. Yong, M. Perez-Rosendahl, F. Jin, D. Dykxhoorn, M. Pericak-Vance, A. Griswold, J. Young, J. Vance.

NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS): 2023 Update
Heather Issen Nicaretta, MS1,2; Amanda B Kuzma, MS1,2; Otto Valladares, MS2,3; Joseph Manuel, BS1,2; Emily Greenfest-Allen, PhD1,4; Prabhakaran Gangadharan, MS1,2; Zivadin Katanic, MS1,2; Maureen Kirsch1,2; Lauren Armus, MS1,2; Naveensri Saravanan, BS1,2; Andrew Wilk, MA1,2; Yi Zhao, MS1,2; Liming Qu, MS1,2; Michelle K Moon1,2; Alexis Lerro Rose1,2; Peter Keskinen1,2; Jeffrey Cifello, BS1,2; Shin-Yi Chou, PhD5; Wan-Ping Lee, PhD2,3; Yuk Yee Leung, PhD1,6,7; Adam C. Naj, PhD2,8; Gerald D. Schellenberg, PhD2,6 and Li-San Wang, PhD1,2,6

Genome-wide identification of modifiers of age-at-onset for Alzheimer’s disease in African American populations
Karen Nuytemans, PhD1,2; Shengru Guo2; Jong ok La, MS3; Adam C. Naj, PhD4,5; Xiaoyi Raymond Gao, PhD6; Yi-Ju Li, PhD3,7; Eden R. Martin, PhD1,2 and the Alzheimer Disease Genetics Consortium,

Genomic editing of APOE4/4 to APOE3/3 in iPSCs bearing African and European local ancestry surrounding APOE
Oded Oron, Ph.D, Brooke DeRosa Ph.D, Farid Rajabli Ph.D, Katrina Celis, MD, Briseida E. Feliciano-Astacio MD, Concepcion Silva, MBA, Gary W. Beecham, Ph.D, Larry D. Adams MS, Sergio Tejada MD, Pedro Mena MD, Patrice Whitehead MS, Kara Hamiliton-Nelson MS, Takiyah D. Starks MS, Goldie S. Byrd Ph.D, Michael L. Cuccaro Ph.D, Juan Young Ph.D, Margaret A. Pericak-Vance, Ph.D, Jeffery M. Vance, MD, Ph.D and Derek M. Dykxhoorn, Ph.D.

The Asian Cohort for Alzheimer’s Disease pilot study at University of California San Francisco: A focus on recruitment of Chinese American older adults
James Qian, MA1; Boon Lead Tee, MD, MS1; Marian Tzuang, PhD, MSW2; Kevin Lieu, BS1; Diana Mei, BS1; Howard J. Rosen, MD3,4; Serggio Lanata, MD, MS1; Li-San Wang, PhD5; Tiffany W Chow, MD6; Gyungah R Jun, PhD7; Van Ta Park, PhD, MPH2,8 and ACAD Consortium

Protective variants in Alzheimer’s Disease from healthy elderly APOE-ε4 participants
Min N Qiao, PhD1; Dolly Reyes-Dumeyer, BS2,3; Martin Medrano, MD4; Rafael A. Lantigua, MD5; Richard Mayeux, MD, MSc6 and Badri N Vardarajan, PhD1

Deciphering the Genomic Regulatory Architecture of iPSC Derived Oligodendrocytes from Diverse Ancestries for Alzheimer’s Disease Studies
A. Ramirez, J. Shepperd, L. Coombs, S. Simon, S. Moura, F. Rajabli, B. DeRosa, M. Muniz, P. Whitehead, L.D. Adams, T.D. Starks, P. Mena, M. Illannes-Manrique, S.J. Tejada, G.S. Byrd, M. Cornejo-Olivas, B. Feliciano-Astacio, R. L. Wang, W. Xu, F. Jin, A. Griswold, J. Young, D. Dykxhoorn, J. Vance.

Comparison of plasma and cerebrospinal fluid protein markers and their significance for the characterization of dementia disease status
Habbiburr Rehman, PhD1; Ting Fang Alvin Ang, MD, MPH2,3; Qiushan Tao1; Xiaoling Zhang, PhD2,4 and Wei Qiao Qiu, M.D., Ph.D1

The association of English-Spanish and Indigenous-Spanish bilingualism with cognition among older adults in the Mexican Health and Aging Study (MHAS)
Miguel Arce Renteria, PhD1; Sarah Petrosyan, MPH2; Joseph Saenz, Ph.D.3; Silvia Mejia Arango, PhD4; Emma Aguila, PhD5; Sandra Barral, PhD6; Giuseppe Tosto, MD, PhD7; Dolly Reyes-Dumeyer, BS7; Rafael Samper-Ternent, MD, PhD8; Alejandra Michaels Obregon, MS8 and Rebeca Wong, PhD8

Challenges of recruitment and biomarkers collection in Caribbean Hispanics
Dolly Reyes-Dumeyer, BS1; Angel Piriz, MD2; Belisa Soriano, MD3; Yahaira Franco, MD4; Zoraida Dominguez Coronado, MD5; Patricia Recio, MD6; Diones Rivera Mejia, MD6; Martin Medrano, MD7; Rafael A. Lantigua, MD1; Badri N Vardarajan, MS, PhD8,9; Lawrence S. Honig, MD, PhD10 and Richard Mayeux, MD, MSc11

Cell-Based Genetic Subtypes Predict Neuroimaging Biomarkers and Clinical Conversion to Alzheimer’s Disease
Nathan Sahelijo1; Priya Rajagopalan, MD2; Dhawal Priyadarshi1; Daniel Goldstein, MS3; Kwangsik Nho, PhD4,5,6; Li Shen, PhD7; Heng Huang, PhD8; Christos Davatzikos, PhD9; Andrew J. Saykin, PsyD5,6,10; Paul M Thompson, PhD11 and Gyungah R Jun, PhD1,12,13

Detecting Protective Rare Variants for Alzheimer’s Disease from Whole-Genome Sequencing in the Amish
Yeunjoo E. Song1,2, Weihuan Wang1, Kristy L. Miskimen1, Renee A. Laux1, M. Denise Fuzzell1, Sarada L. Fuzzell1, Sherri D. Hochstetler1, Leighanne R. Main2,3, Michael D. Osterman1,2, Audrey Lynn1,2, Michael B. Prough4, Susan H. Slifer4, Larry D. Adams4, Laura J. Caywood4, Jason E. Clouse4, Sharlene D. Herington4, Daniel A. Dorfsman4, Jeffrey M. Vance4,5, Michael L. Cuccaro4,5, Paula K. Ogrocki6,7, Alan J. Lerner6, William K. Scott4,5, Margaret A. Pericak-Vance4,5, and Jonathan L. Haines1,2,3

Bilingualism and APOE4 alelle as a risk-protective factor in dementia among Peruvian Andean aging population
Marcio F. Soto-Añari, PhD1; Claudia Rivera-Fernandez2; Luis Ramos-Vargas Sr., MSc3; Nilton Custodio, MD, PhD4; Rosa Montesinos, MD5; Diego Chambergo-Michilot6,7; Maria Fernanda Ore-Gomez, PhD8; Jose Carreño-Galvez, MSc9; Dolly Reyes-Dumeyer, BS10 and Giuseppe Tosto, MD, PhD10

Perceptions of Brain donation and Medical Research Among African American Individuals: Implications for Recruitment and Retention into Alzheimer’s Research
Takiyah D. Starks, BS, MS1; Allison M Caban-Holt, PhD1; Michael L. Cuccaro2; Tayla Ford, MS1; Shawnta’ Lloyd, Ph.D.1; Larry D. Adams3; Johnathan L Haines, PhD4; Christiane Reitz, PhD, MD5; Jeffery M. Vance3,6; Margaret A. Pericak-Vance3,6 and Goldie S. Byrd, PhD7

Characterization of an African ancestry-specific protective allele of the APOE ε4 allele for Alzheimer’s disease risk
L. Wang, M. Lipkin Vasquez, F. Rajabli, K. Nuytemans , P. Whitehead, M. Gearing, D. Bennett, M. Flanagan, S. Weintraub, C. Geula, W. Scott, T. Schuck, F. Jin, W. Xu, D. Dykxhoorn, M. Pericak-Vance, A. Griswold, J. Young, J. Vance.

Distinct CSF biomarker-associated DNA methylation in Alzheimer’s disease and cognitively normal subjects
Lily Wang, PhD1,2,3,4; Wei Zhang4; Juan I. Young, PhD1,3; Lissette Gomez, MS1; Michael A. Schmidt, PhD1,5; David Lukacsovich4; Achintya Varma, PhD4; Xi Chen5; Brian W. Kunkle, PhD, MPH1,4,5,6 and Eden R. Martin, PhD3,7

Asian Cohort for Alzheimer’s Disease Pilot Study on Genetic and Non-Genetic Risk Factors for Alzheimer’s Disease among Asian Americans and Canadians
Li-San Wang, PhD1; Pei-Chuan Ho, PhD1; Boon Lead Tee, MD, MS2; Clara Li, PhD3; Yian Gu, PhD4; Jennifer S. Yokoyama, PhD2; Dolly Reyes-Dumeyer, BS5; Kelley M. Faber, MS6; Wan-Ping Lee, PhD1; Yeunjoo E. Song7; Marian Tzuang, PhD, MSW8; Badri N Vardarajan, MS, PhD4; Hyun-Sik Yang, MD9; Yun-Beom Choi, PhD, MD10; Howard H. Feldman, MD11; Victor Henderson, PhD, MD12; Ging-Yuek Robin Hsiung, MD, MHSc13; Richard Mayeux, MD, MSc5; Howard J. Rosen, MD2; Rohit Varma, MD, MPH14; Tatiana M. Foroud, PhD6; Walter A. Kukull, PhD15; Guerry M. Peavy, PhD16; Haeok Lee, PhD, RN17; W. Haung Yu, PhD18; Helena C Chui, MD19; Gyungah R Jun, PhD20; Van Ta Park, PhD, MPH8; Tiffany W Chow, MD21 and The Asian Cohort for Alzheimer’s Disease Study

Hi-C analysis in frontal cortex using local ancestry identifies ancestry-specific chromatin 3D interactions
Liyong Wang, Wanying Xu, Xiaoxiao Liu, Farid Rajabli, Katrina Celis, Leina Lu, Marla. Gearing, David A. Bennett, Margaret. Flanagan, Sandra. Weintraub, Changiz Geula, Theresa Schuck, W. Scott, Derek M. Dykxhoorn, Anthony Griswold, Margaret A. Pericak-Vance, Juan I. Young, Fulai Jin, Jeffery M. Vance

Both clinically informed and brain region agnostic approaches identify neuroimaging derived phenotypes associated with genetically regulated gene expression of late-onset Alzheimer’s disease genes
Ting-Chen Wang, B.S.1; Xavier Bledsoe, BA2; Douglas Shaw, BS3; Hung-Hsin Chen, PhD2,3; International Genomics of Alzheimer’s Project (IGAP)4; Adam C. Naj, PhD5; William S. Bush, PhD6,7; Eric J Gamazon, PhD2 and Jennifer E. Below, PhD3,8

Applying Community Based Participatory Practices to Recruitment for the Asian Cohort for Alzheimer’s Disease
W. Haung Yu, PhD1,2; Jake McCallum, BS2; Eleanor Lam, BS2; Michelle Deng, BS2; Xiang Helen Li2; Sephera Chou2 and Li-San Wang, PhD3

 

 

 

CADRE Investigators AAIC 2022 CADRE-related Abstracts:

Diverse Ancestral Populations and the Alzheimer’s Disease Sequencing Project (ADSP)

Brian W. Kunkle, PhD, MPH1,2 for the Alzheimer’s Disease Sequencing Project (ADSP)

 

Association Analysis on Alzheimer’s Disease Sequencing Project (ADSP) 16,905 Whole-Genome Sequence Data
Wan-Ping Lee, PhD1,2, Gina M Peloso, PhD3, Achilleas N Pitsillides, PhD3, Nancy Heard-Costa, PhD4,5, Hui Wang, PhD1·2, Yuk Yee Leung, PhD1·6, Jonathan L. Haines, PhD7·8, Anita L. Destefano, PhD3·4 and Collaboration on Alzheimer’s Disease Research (CADRE), and The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)

Multi-Ancestry Genome-wide Association Analysis of Late-Onset Alzheimer’s Disease (LOAD) in 60,941 Individuals Identifies a Novel Cross-Ancestry Association in LRRC4C
Adam C. Naj, PhD1,2, Christiane Reitz, PhD, MD3,4, Farid Rajabli, PhD5, Gyungah R. Jun, PhD6,7, PenelopeBenchek, PhD8, Giuseppe Tosto, MD, PhD3,4, Jin Sha, MS1, Congcong Zhu, MS6, Nicholas A. Kushch5, Wan-Ping Lee, PhD2,9, Jacob Haut, BS1, Kara L. Hamilton-Nelson, MPH5,10, Nicholas R. Wheeler, PhD8, Yi Zhao, MS2, John Farrell, PhD6, Jaeyoon Chung, PhD6, Michelle Grunin, PhD8, Yuk Yee Leung, PhD2,9,Donghe Li, PhD6, Eder Lucio da Fonseca, PhD5, Jesse B. Mez, MD, MS6,11, Ellen L Palmer, PhD8, Jagan A. Pillai, MD, PhD12,13, Richard Sherva, PhD6,14, Yeunjoo E. Song, PhD8, Xiaoling Zhang, PhD6,7, Taha Iqbal, MS1, Omkar Pathak, MS2, Otto Valladares, MS2,9, Amanda B. Kuzma, MS2,9, Brian W. Kunkle, PhD, MPH5,10, William S. Bush, PhD8, Li-San Wang, PhD2,9, Lindsay A. Farrer, PhD6,7, Jonathan L. Haines, PhD8, Richard Mayeux, PhD, MD3,4, Margaret A. Pericak-Vance, PhD5,10, and Gerard D. Schellenberg, PhD2 for the Alzheimer’s Disease Genetics Consortium (ADGC)

African-ancestry based polygenic risk scores improve Alzheimer disease risk prediction in individuals of African Ancestry.
Bilcag Akgun, Kara L. Hamilton-Nelson, Nicholas A. Kushch, Larry D. Adams, Takiyah D. Starks, Izri M. Martinez Soto, Renee A. Laux, Patrice L. Whitehead, Brian Kunkle, Alzheimer’s Disease Genetic Consortium, Michael L. Cuccaro, Jeffery M. Vance, Christiane Reitz, Goldie S. Byrd, Jonathan L. Haines, Gary W. Beecham, Margaret A. Pericak-Vance, Farid Rajabli.

Fine-mapping of chromosome 9p21 linkage in Puerto Rican Alzheimer disease families.
Katrina Celis, Farid Rajabli, Shaina A. Simon, Liyong Wang, Kara L. Hamilton-Nelson, Larry D. Adams, Pedro R. Mena, Sergio Tejada, Patrice L. Whitehead, Derek J. Van Booven, Briseida E. Feliciano-Astacio, Angel Chinea, Nereida I. Feliciano, Heriberto Acosta, Clifton L. Dalgard, Jonathan L. Haines, Fulai Jin, Jeffery M. Vance, Michael L. Cuccaro, Gary W. Beecham, Derek M. Dykxhoorn, Anthony J. Griswold, Margaret A. Pericak-Vance.

Ancestral Analysis of the Presenilin-1 G206A Variant Reveals it as a Founder Event on an African Haplotype in the Puerto Rican Population
Kara L. Hamilton-Nelson1, Anthony J. Griswold1,2, Farid Rajabli1, Patrice L. Whitehead1, Maricarmen Contreras1, Sergio Tejada1, Pedro R. Mena1, Jose Javier Sanchez1, Larry D. Adams1, Takiyah D. Starks3, Concepcion Silva4, Michael L. Cuccaro1,2, Jeffery M. Vance1,2, Goldie S. Byrd3, Jonathan L. Haines5,6, Gary W. Beecham1,2, Briseida E. Feliciano-Astacio4, and Margaret A. Pericak-Vance1,2

 

Characterization of chromosome 5q35 risk locus in African Ancestry population.
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, The NIA-LOAD Family-Based Study, Mike L. Cuccaro, Jeffery M. Vance, Jonathan L. Haines, Christiane Reitz, Goldie S. Byrd, Gary W. Beecham, Margaret A. Pericak-Vance

A Novel Protective locus significantly reduces the ApoE ε4 risk for Alzheimer’s Disease in African Ancestry.
Marina Lipkin-Vasquez1, Farid Rajabli1, Gary W. Beecham1,2 ,Hugh C. Hendrie3, Olusegun Baiyewu4, Adesola Ogunniyi4, Sujuan Gao5, Nicholas A. Kushch1, Kara L. Hamilton-Nelson1, Juan Young1,2, Derek M. Dykxhoorn1,2, Karen Nuytemans1,2, Brian W. Kunkle1,2, Liyong Wang1,2, Fulai Jin6 , Xiaoxiao Liu6, Briseida E. Feliciano-Astacio7, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium, Clifton L. Dalgard8, Anthony J. Griswold1,2, Goldie S Bird9, Christiane Reitz10, Jonathan L. Haines11, Margaret A. Pericak-Vance1,2, Jeffery M. Vance1,2.

Novel Loci for Alzheimer Disease Identified by Genome Wide Association Study in Ashkenazi Jews
Donghe Li1, John J Farrell1, Jesse Mez2, Eden R. Martin6,7, William S. Bush9, Richard Mayeux10, Jonathan L. Haines9, Margaret A. Pericak Vance6-8, Li-San Wang11, Gerard D. Schellenberg11, Kathryn L. Lunetta4, Lindsay A. Farrer1-5

 

Multiple Viruses Detected in Human DNA are Associated with Alzheimer Disease Risk
Marlene Tejeda1, John Farrell1, Congcong Zhu1, Lee Wetzler2,3, Kathryn L. Lunetta4, William S. Bush5, Eden R. Martin6, Li-San Wang7, Gerard Schellenberg7, Margaret A. Pericak-Vance6, Jonathan L. Haines5, Lindsay A. Farrer1,4, Richard Sherva1

Variants near X-Chromosome Genes NLGN4X and PTCHD1 are Significantly Associated with Alzheimer’s Disease Risk
Jaeyoon Chung1, Xinyu Sun1, Mike Schmidt6, Yeunjoo E. Song7,8, Michelle Grunin7, Ellen Palmer7, William Bush7, Adam C Naj9, Farid Rajabli6, Kara L Hamilton-Nelson6, Xiaoling Zhang1,4, Yuk Yee Leung9, Li-San Wang9, Richard Mayeux10, Gerald D Schellenberg9, Margaret A Pericak-Vance6, Jonathan L. Haines7,8, Lindsay A. Farrer1-5, Brian W Kunkle6, Eden R Martin6

Assessing a Network-Specific Polygenic Risk Score for Alzheimer’s Disease in the Midwestern Amish and Across Diverse Ancestries
Michael D. Osterman1,2, Yeunjoo E. Song1, Nicholas R. Wheeler1, Renee A. Laux1, Larry D. Adams3, Laura J. Caywood3, Michael B. Prough3, Jason E. Clouse3, Sharlene D. Herington3, Susan H. Slifer3, Audrey Lynn1, Jacquelaine Bartlett1, M. Denise Fuzzell1, Sarada L. Fuzzell1, Sherri D. Hochstetler1, Kristy L. Miskimen1, Leighanne R. Main2,4, Daniel A. Dorfsman3,5, Paula Ogrocki6,7, Alan J. Lerner6,7, Jeffery M. Vance3,5, Michael L. Cuccaro3,5, William S. Bush1,2, William K. Scott3,5, Margaret A. Pericak-Vance3,5, Jonathan L. Haines1,2, Alzheimer’s Disease Sequencing Project (ADSP)

Identification of Genetic Variants and Serum Metabolites Associated with Blood-derived Mitochondrial DNA Copy Number
Tong Tong1,2, John J. Farrell2, Congcong Zhu2, Zainab Khurshid1,2, Eden R. Martin3, William Bush4, Margaret A. Pericak-Vance3, Li-San Wang5, Gerard Schellenberg5, Jonathan L. Haines4, Kathryn L. Lunetta6, Lindsay A. Farrer1,2,6, and Xiaoling Zhang1,2,6 on behalf of the Alzheimer’s Disease Sequencing Project (ADSP)

Association of short tandem repeats with neuropathological features in late-onset of Alzheimer’s disease brains
Annie J. Lee1,2, Hans Ulrich-Klein3,7 Julie A. Schneider4,5,6, David A. Bennett4,5, Philip L. De Jager1,2,3,7, Giuseppe Narzisi8, Mike Zody8, Badri N. Vardarajan1,2,3

CADRE Investigators’ Other AD-Related (non-ADSP) AAIC 2022 Submitted Abstracts

Genomic assessment of early-onset AD identifies novel risk loci and an incomplete genetic overlap with late-onset AD.

Eder L. da Fonseca, PhD1, Melissa J. Francois, MPH1, Jiji T. Kurup, PhD2, Chengran Yang, PhD3, Susan H. Slifer, PhD1, Eden R. Martin, PhD1, Brian W. Kunkle, PhD1, Adam Naj, PhD4, Lindsay A. Farrer, PhD5, Jonathan L. Haines, PhD6, Richard P. Mayeux, PhD7, Gerard D. Schellenberg, PhD8, Margaret A. Pericak-Vance, PhD1, Maria V. Fernandez, PhD3, Carlos Cruchaga, PhD3, Christiane Reitz, PhD2, Gary W. Beecham, PhD1, and the Alzheimer Disease Genetics Consortium (ADGC).

 

Analysis of Alzheimer Disease Plasma Biomarker pTau-181 in Individuals of Diverse Admixed Ancestral Backgrounds

Anthony J. Griswold1,2, Farid Rajabli1, Catherine Garcia-Serje1, Jamie Arvizu1, Emma Larkin-Gero1, Patrice L. Whitehead1, Kara L. Hamilton-Nelson1, Larry D. Adams1, Maricarmen Contreras1, Jose Javier Sanchez1, Sergio Tejada1, Pedro R. Mena1, Takiyah Starks3, Mario R Cornejo-Olivas4, Maryenela Illanes-Manrique4, Concepcion Silva5, Michael L. Cuccaro1,2, Jeffery M. Vance1,2, Briseida E. Feliciano-Astacio5, Goldie S. Byrd3, Gary W. Beecham1,2, Jonathan L. Haines6,7, and Margaret A. Pericak-Vance1,2

 

Depressive Symptoms Associated with an Earlier Age at Onset Differ as a Function of Race-Ethnicity: An Exploratory Analysis
Andrew Zaman, PhD1, Pedro Ramon Mena, MD2, Larry D. Adams1, Maricarmen Contreras, BA1, Faina C Lacroix, MPH1, Sergio Tejada, MD1, Takiyah D. Starks, BS, MS1, Briseida E. Feliciano-Astacio, MD3, Concepcion Silva, MBA3, Allison M Caban-Holt, PhD4, Goldie S. Byrd, PhD4, Izri Martinez, MD5, Temitope Ayodele, BS5, Penelope Baez5, Gabrielle Blackshire6, Sara Kennedy, PhD6, Christiane Reitz, PhD, MD7, Jonathan L. Haines, PhD8,9, Jeffery M. Vance, MD, PhD1, Margaret A. Vance, PhD1 and Michael L. Cuccaro, PhD1,

Differentially methylated CpG sites between APOE ε4 carriers and non-carriers in blood and brain from Alzheimer disease cases and controls
Rebecca Panitch1, Rhoda Au2-5,8, Thor Stein2-4, Lindsay A. Farrer1-8, Gyungah R. Jun1,3,4,6

Bulk brain tissue cell type deconvolution with bias correction for single-nuclei RNA-seq
Nicholas O’Neill1,2, Junming Hu1,2, Thor D. Stein4, Xiaoling Zhang1,2,3, Lindsay A. Farrer1,2,3

Gene Expression Differences Between Symptomatic and Asymptomatic Individuals with Neuropathologically Confirmed Alzheimer’s Disease
Yuehting Wang1, Donghe Li1, Ting F.A. Ang2, Weiming Xia3,9, Rhoda Au2,4,7, Lindsay A. Farrer1,4,6-8, Thor D. Stein5,9, Gyungah R. Jun1,6,8

A Genome-Wide Search for Pleiotropy in Cognitive Domain Scores
Moonil Kang1, Jesse B. Mez2, Ting Fang Alvin Ang3, 4, 5, Sherral A. Devine3, 4, Shubhabrata Mukherjee6, Emily H. Trittschuh7, 8, Andrew J. Saykin9, 10, 11, Paul K. Crane6, 12, Rhoda Au2, 3, 4, 5, 13, Kathryn L. Lunetta14, and Lindsay A. Farrer1, 2, 13, 14, 15

Collection of genetic data in ethnic-based studies across Aymaras, Quechuas and Mestizos: the challenges of the Genetics of Alzheimer’s in Peruvian Population (GAPP) study.
Dolly Reyes-Dumeyer1,2,3, Rosa Montesinos4, Maritza Pintado-Caipa4, Maria Fernanda Oré- Gómez5, Claudia Rivera-Fernandez6, Marcio Soto-Añari6,7, Nilton Custodio4, Giuseppe Tosto1,2,3

Native American Ancestry is associated with lower risk of Alzheimer’s Disease: results from the Genetic of Alzheimer’s disease in Peruvian Populations (GAPP) study.
Nilton Custodio, PhD, MD1, Marcio Soto-Anari, PhD2, Rosa Montesinos, MD3, Maritza Pintado-Caipa, MD1, Maria Fernanda Oré- Gómez, PhD4, Claudia Rivera-Fernandez, Psicologa5,Dolly Reyes-Dumeyer, BS6, Giuseppe Tosto, MD, PhD6

Hearing loss and dementia in Peruvian Populations
Nilton Custodio, PhD, MD1, Virgilio E Failoc-Rojas, MA2, Diego Chambergo-Michilot, MS3, Diego Malaga2, Maria Fernanda Oré- Gómez, PhD4, Claudia Rivera-Fernandez, Psicologa5,Marcio Soto-Anari, PhD6, Dolly Reyes-Dumeyer, BS7, Sandro Casavilca-Zambrano8, Rosa Montesinos, MD2, Giuseppe Tosto, MD, PhD7

IMPACT OF THE COVID-19 PANDEMIC IN ADRD PATIENTS AND CAREGIVERS IN A LATIN-AMERICAN COUNTRY
Nilton Custodio, PhD, MD1, Diego Malaga2, Diego Chambergo-Michilot, MS3, Maria Fernanda Oré- Gómez, PhD4, Claudia Rivera-Fernandez, Psicologa5,Marcio Soto-Anari, PhD6, Dolly Reyes-Dumeyer, BS7, Virgilio E Failoc-Rojas, MA2, Sandro Casavilca-Zambrano8, Rosa Montesinos, MD2 and Giuseppe Tosto, MD, PhD7

Association between nutritional status and dementia staging among Alzheimer’s disease patients in Peru: Preliminary results of the Genetic of Alzheimer’s Disease in Peruvian Population Study
Rosa Montesinos, MD1, Diego Chambergo-Michilot, MS2, Diego Malaga1, Maria Fernanda Oré- Gómez, PhD3, Claudia Rivera-Fernandez, Psicologa4,Marcio Soto-Anari, PhD5, Dolly Reyes-Dumeyer, BS6, Virgilio E Failoc-Rojas, MA1, Sandro Casavilca-Zambrano7, Nilton Custodio, PhD, MD1,8 and Giuseppe Tosto, MD, PhD6

CADRE Investigators AAIC 2021 CADRE-related Abstracts:

Admixture Mapping Identifies Novel Regions Influencing Alzheimer Disease in African Americans
K.L Hamilton-Nelson1, F. Rajabli1, B.W. Kunkle1, G. Tosto2, C. Reitz2, A. Naj3, P. Whitehead1, N.A. Kushch1, G.W. Beecham1,7, GS Byrd5, W.S. Bush4, R. P. Mayeux2, L.A. Farrer6, J.L Haines4, G.D. Schellenberg3, M.A. Pericak-Vance1,7, E.R. Martin1,7, for the Alzheimer’s Disease Genetics Consortium (ADGC), and Collaboration on Alzheimer’s Disease Research (CADRE) of the Alzheimer’s Disease Sequencing Project (ADSP)

Genetic factors underlying sex differences in resilience to Alzheimer’s disease
Jaclyn M. Eissman1,2, Logan Dumitrescu,1,2 Emily R. Mahoney,1,2 Shubhabrata Mukherjee,3 Michael L. Lee,3 William S. Bush,4 Corinne D. Engelman,5 Qiongshi Lu,6,7 David W. Fardo,8,9 Emily H. Trittschuh,10,11 Jesse Mez,12 Catherine Kaczorowski,13 Hector Hernandez Saucedo,14 Keith F. Widaman,15 Rachel Buckley,16,17,18 Michael Properzi,16 Elizabeth Mormino,19 Hyun-Sik Yang,16,17 Tessa Harrison,20 Trey Hedden,21 Kwangsik Nho,22,23 Shea J. Andrews,21 Doug Tommet,24 Niran Hadad,13 R. Elizabeth Sanders,3 Douglas M. Ruderfer,2 Katherine A. Gifford,1 Xiaoyuan Zhong,6,7 Neha S. Raghavan,25,26,27 Badri Vardarajan,25,26,27 The Alzheimer’s Disease Neuroimaging Initiative (ADNI),* Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Margaret A. Pericak-Vance,28 Lindsay A. Farrer,12,29,30 Li-San Wang,31 Carlos Cruchaga,32 Gerard Schellenberg,31 Nancy J. Cox,2 Jonathan L. Haines,4 C. Dirk Keene,33 Andrew J. Saykin,34 Eric B. Larson,3,35 Reisa A. Sperling,16 Richard Mayeux,25,26,27, Michael Cuccaro28, David A. Bennett,36 Julie A. Schneider,36 Paul K. Crane,3 Angela L. Jefferson,1 and Timothy J. Hohman1,2

Expression quantitative trait loci (eQTL) analysis in a diverse Alzheimer disease cohort reveals ancestry specific regulatory architectures
Anthony J. Griswold1,2, Olivia K. Gardner1,2, B.E. Feliciano-Astacio4 Derek Van Booven1, Kara L. Hamilton-Nelson1, Patrice L. Whitehead1, Larry D. Adams1, Takiyah D. Starks3, , H. Acosta5, Michael L. Cuccaro1,2, Jeffery M. Vance1,2, Goldie S. Byrd3, Jonathan L. Haines6, William S. Bush6, Gary W. Beecham1,2, and Margaret A. Pericak-Vance1,2

Assessment of AD Related Plasma Biomarkers in Diverse Ancestral Populations
Anthony J. Griswold1,2, Farid Rajabli1, Catherine Garcia-Serje1, Kara L. Hamilton-Nelson1, Larry D. Adams1, Sergio Tejada1, Pedro R. Mena1, Takiyah Starks3, Patrice L. Whitehead1, Concepcion Silva4, Michael L. Cuccaro1,2, Izri M. Martinez Soto5, Maryenela Illanes-Manrique6, Mario Cornejo-Olivas6, Renee A. Lauz7, Laura Caywood1, Christiane Reitz5, Gary W. Beecham1,2, Goldie S. Byrd3, Briseida E. Feliciano-Astacio4, William K Scott1,2 Jonathan L. Haines7,8, Jeffery M. Vance1,2, and Margaret A. Pericak-Vance1,2

APOE-stratified genome-wide association analysis identifies novel Alzheimer disease candidate risk loci for African Americans
Brian W. Kunkle, PhD1, Melissa Jean-Francois, MPH1, Kara L. Hamilton-Nelson, MPH1, Mike Schmidt PhD1, Adam Naj, PhD2 Alzheimer’s Disease Genetics Consortium (ADGC), Eden R. Martin, PhD1, Jeffery M. Vance, MD, PhD1, Michael L. Cuccaro, PhD1, Farid Rajabli, PhD1 Gyungah Jun, PhD2, Li-San Wang5, Lindsay A. Farrer, PhD2, Jonathan L. Haines, PhD3, Goldie S. Byrd, PhD4, Gerard D. Schellenberg, PhD5, Richard Mayeux, MD, MSc6, Gary Beecham, PhD1, Margaret A. Pericak-Vance, PhD1, Christiane Reitz, MD, PhD6

Does Higher educational attainment influence functional capabilities among African Americans with Alzheimer’s Disease?
Faina C Lacroix 1, Larry D. Adams1, Jovita Inciute1, Jacob Welch1, Takiyah Starks2, Renee Laux 3,4, Goldie S Byrd2, Jonathan L Haines3,4, Gary Beecham1,5, Michael L Cuccaro1,5, Jeffery M Vance1,5,, Margaret A. Pericak-Vance1,5 and Farid Rajabli1

African locus reduces the effect of ApoE ε4 allele in Alzheimer’s disease
Farid Rajabli1, Brian W. Kunkle1,6, Christiane Reitz2, Hugh C. Hendrie3, Olusegun Baiyewu4, Adesola Ogunniyi4, Sujuan Gao5, Nicholas A. Kushch1, Kara L. Hamilton-Nelson1, Alzheimer’s Disease Sequencing Project, Alzheimer’s Disease Genetic Consortium, Gary W. Beecham1,6, Margaret A. Pericak-Vance1,6, Jeffery M. Vance1,6

Multiple Viruses Detected in Human DNA are Associated with Alzheimer Disease Risk
Marlene Tejeda1, John Farrell1, Congcong Zhu1, Jonathan L. Haines2, Li-San Wang3, Gerard Schellenberg4, Margaret A. Pericak-Vance5,6, William S. Bush2, Eden R. Martin5,6, Lindsay A. Farrer1, Richard Sherva1

 

 

 

CADRE Investigators AAIC 2020 CADRE-related Abstracts:

Exploring the role of Amerindian genetic ancestry and ApoEε4 gene on Alzheimer disease in the Peruvian population. M. Cornejo¬-Olivas, Farid Rajabli, Veliz¬-Otani, P. Whitehead, Natalia K. Hofmann , Kara Hamilton-Nelson, M. Illanes-Manrique, K. Milla¬-Neyra, V. Marca, E. Sarapura-Castro, A. Rivera-Valdivia, C. Mejia-Rojas, Larry D. Adams, Pedro R. Mena, Jeffrey M. Vance, R. Isasi, Michael L. Cuccaro, Gary W. Beecham, S. Castro-¬Suarez, M. Meza, N. Custodio, R. Montesinos, P. Mazzetti, and Margaret A. Pericak-Vance

Using Linkage to Identify Novel Gene-Gene Interactions in Alzheimer’s Disease. Michelle Grunin, Nicholas R. Wheeler, William S. Bush, Jonathan L. Haines, and the Alzheimer’s Disease Sequencing Project
Genome-wide profiling of the noncoding regulatory mechanisms in Alzheimer’s Disease. Lauren Kleidermacher, Pavel Kuksa, Chien-Yueh Lee, Alexandre Amlie-Wolf, Gerard D. Schellenberg, Li-San Wang, and Yuk Yee Leung

Sex-specific genome-wide meta-analysis identifies novel candidate genes for Alzheimer disease. Brian W. Kunkle, Celine BellenguezOmar Garcia Rodriguez, Kara L. Hamilton-Nelson, Melissa Jean-Francois, Adam C. Naj, Detelina Grozeva, Rebecca Sims, Ganna Leonenko, Lily Wang, Amanda B. Kuzma, Gary W. Beecham, William S. Bush, Timothy Hohman, Jaeyoon Chung, Alzheimer Disease Genetics Consortium (ADGC), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), The European Alzheimer’s Disease Initiative (EADI), Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Valentina Escott-Price, Li-San Wang, Richard Mayeux, Jonathan L. Haines, Lindsay A. Farrer, Sudha Seshadri, Gerard D. Schellenberg, Philippe Amouyel, Margaret A. Pericak-Vance, Julie Williams, Jean-Charles Lambert, Myriam Fornage, and Eden R. Martin for The International Genomics of Alzheimer’s Project (IGAP)

Comparative Trans-Ethnic Meta-Analysis of Whole Exome Sequencing Variation for Alzheimer’s Disease (AD) in 18,402 individuals of the Alzheimer’s Disease Sequencing Project (ADSP). Adam C. Naj, Farid Rajabli, Kara L. Hamilton-Nelson, Brian W. Kunkle, Xueqiu Jian, Yanbing Wang, Gina Peloso, Honghuang Lin, Chloé Sarnowski, Achilleas Pitsillides, Claudia Satizabal, William S. Bush, Timothy A. Thornton, Ellen Wijsman, Sudha Seshadri, Jonathan L. Haines, Josée Dupuis, Goldie S. Byrd, Eden R. Martin, Margaret A. Pericak-Vance, and Myriam Fornage, on behalf of the Alzheimer Disease Sequencing Project.

Structural characterization of rare missense variants within known neurodegenerative disease proteins. Ellen L. Palmer, Christopher Moth, Penelope Benchek, Nicholas R. Wheeler, Brian W. Kunkle, Kara L. Hamilton-Nelson, Anthony J. Griswold, Adam C. Naj, Lindsay A. Farrer, Eden R. Martin, Margaret A. Pericak-Vance, Jonathan L. Haines, Jonathan H. Sheehan, John A. Capra, and William S. Bush
Assessing whole genome sequencing variation for Alzheimer’s disease in 4707 individuals from the Alzheimer’s disease Sequencing Project (ADSP). Gina Peloso, Yanbing Wang, Honghuang Lin, Chloé Sarnowski, Achilleas Pitsillides, Elise Lim, Gary W. Beecham, Kara Hamilton-Nelson, Jairo Ramos, Eden R. Martin, Adam C. Naj, Timothy A. Thornton, Li-San Wang, Eric Boerwinkle, Lindsay A. Farrer, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Sudha Seshadri, Gerard D. Schellenberg, Ellen M. Wijsman, Myriam Fornage, Josée Dupuis, Anita L DeStefano, and Brian W. Kunkle, on behalf of the Alzheimer’s Disease Sequencing Project.

Southern European genetic ancestry shows reduced APOE e4 risk for Alzheimer disease in Caribbean Hispanic population. Farid Rajabli, Larry D. Adams, Sergio Tejada, Vanessa C. Rodriguez, Pedro R. Mena, Michael Prough, Parker Bussies, Nereida I. Feliciano, Concepcion Silva, Maricarmen Contreras, Kara L. Hamilton-Nelson, Heriberto Acosta, Jeffery M. Vance, Michael L. Cuccaro, Briseida E. Feliciano-Astacio, Gary W. Beecham, and Margaret A. Pericak-Vance

High Frequency of Progranulin Mutations in Caribbean Hispanic Families with Dementia. Badri N. Vardarajan, Dolly Reyes-Dumeyer, Angel Piriz, Martin Medrano, Rafael Lantigua, and Richard Mayeux

Functional Analysis of Candidate Genes Identified through Whole Genome Sequencing in Caribbean Hispanic Families for Late-onset Alzheimer Disease. L. Wang, Holly N. Cukier, Farid Rajabli, Natalia K. Hofmann, Larry D. Adams, Vanessa C. Rodriguez, Pedro R. Mena, C. Garcia Serje, Concepcion Silva, Nereida I. Feliciano, Briseida E. Feliciano-Astacio, Heriberto Acosta, Jeffrey M. Vance, Gary W. Beecham, and Margaret A. Pericak-Vance

Tissue-Specific Analysis of Rare Genetic Variation for Alzheimer’s Disease. Nicholas R. Wheeler, Penelope Benchek, Brian W. Kunkle, Kara L. Hamilton-Nelson, Anthony J. Griswold, Adam C. Naj, Lindasy A. Farrer, Eden R. Martin, Margaret A. Pericak-Vance, Jonathan L. Haines, William S. Bush, and the Alzheimer’s Disease Sequencing Project
Age Stratified Analysis to Identify Genetic Loci with Age-Dependent Effects on the Risk of Late-onset Alzheimer Disease. Zhang X, Yiyi Ma, Congcong Zhu, John Farrell, Jaeyoon Chung, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Schellenberg G, Kathryn L. Lunetta, and Lindsay A. Farrer

 

CADRE Investigators’ Other AD-Related (non-ADSP) AAIC 2020 Submitted Abstracts

Education and its Effect on Risk and Age at Onset in Alzheimer Disease (AD) in African Americans. Larry D. Adams, Susan H. Slifer, Jairo Ramos, Jovita Inciute, Takiyah Starks, Aja Scott, Faina C. LaCroix , Renee A. Laux, Jonathan L Haines, Jeffery M. Vance, Michael L. Cuccaro, Goldie S. Byrd, Gary W. Beecham, and Margaret A. Pericak-Vance

Sex-Specific Cross-Phenotype Analysis of Alzheimer’s Disease and Cerebral Small Vessel Diseases. C. Anderson, Jaeyoon Chung, S. Marini, Zhang X, Jesse Mez, Gyungah R. Jun, B. Mitchell, Brian W. Kunkle, Eden R. Martin, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Kathryn L. Lunetta, J. Rosand, and Lindsay A. Farrer

Multi-modal genome-wide meta-analysis of brain amyloidosis reveals heterogeneity across CSF, PET, and pathological amyloid measures. Derek B. Archer, Emily R. Mahoney, Logan Dumitrescu, Angela L. Jefferson, William Jagust, Susan M. Resnick, Murat Bilgel, Sterling C. Johnson, Corinne D. Engelman, Henrik Zetterberg, Kaj Blennow, Yuetiva Deming, Reisa A. Sperling, Keith A. Johnson, Rachel F. Buckley, A4 Study, Eric Larson, Walter A. Kukull, C. Dirk Keene, Thomas Montine, Gary Beecham, Gerard D. Schellenberg, Julie A. Schneider, David A. Bennett, Richard P. Mayeux, Carlos Cruchaga, Timothy J. Hohman
Genome wide association study of chronic traumatic encephalopathy. K. Atherton, M.M. Khan, C. Shea, Jaeyoon Chung, E. Nair, Z.H. Baucom, B. Abdolmohammadi, M. Uretsky, B.M. Martin, J.N. Palmisano, K. Farrell, J. Cherry, V.E. Alvarez, B.R. Huber, M.L. Alosco, Kathryn L. Lunetta, Y. Tripodis, T.D. Stein, Lindsay A. Farrer, J.F. CrarY, A.C. McKee, and Jesse Mez

Genome-wide gene-based analysis of episodic memory trajectories in the Mexican Health and Aging Study (MHAS). Sandra Barral, Yizhe Gao, Silvia Mejia Arango, Alejandra Michaels-Obregon, Rafael Samper-Ternent, Rebeca Wong, Richard Mayeux, Dolly Reyes-Dumeyer, and Giuseppe Tosto

Increased APOEε4 expression is associated with reactive A1 astrocytes and may confer the difference in Alzheimer Disease risk from different ancestral backgrounds. Katrina Celis, Anthony J. Griswold, P. Bussies, Farid Rajabli, P. Whitehead, Kara Hamilton-Nelson, Gary W. Beecham, Derek M. Dykxhoorn, Karen Nuytemans, L. Wang , Olivia K. Gardner, D. Dorfsman, E.H Bigio, M. Mesulam, S. Weintraub, C. Geula, M. Gearing, Clifton L. Dalgard, William K. Scott, Jonathan L. Haines, Margaret A Pericak-Vance, J.I. Young, and Jeffrey M. Vance

Genome-Wide SNP Interaction Tests with Polygenic Risk Score for Intracerebral Hemorrhage Identifies Association with Alzheimer Disease at FSTL5 Jaeyoon Chung, S. Marini, Jesse Mez, Zhang X, H. Yang, Gyungah R. Jun, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Kathryn L. Lunetta, J. Rosand, C. Anderson, and Lindsay A. Farrer

Identification of small RNA biomarkers for Alzheimer’s Disease. Kaylyn Clark, Yuk Yee Leung and Li-San Wang

iPSC-Derived Neurons and Microglia with an African-Specific ABCA7 Frameshift Deletion Have Impaired Function. Holly N. Cukier, Juliana Laverde-Paz, Juliana Ramirez, Larry D. Adams, Takiyah D. Starks, Jeffery M. Vance, Michael L. Cuccaro, Mathew Blurton-Jones, Jonathan L. Haines, Goldie S. Byrd, Margaret A. Pericak-Vance, and Derek M. Dykxhoorn

Sex differences in genetic predictors of resilience to Alzheimer’s disease. Logan Dumitrescu, Emily R. Mahoney, Shubhabrata Mukherjee, Michael L. Lee, William S. Bush, Corinne D. Engelman, Qiongshi Lu, David W. Fardo, Emily H. Trittschuh, Jesse Mez, Catherine Kaczorowski, Keith F. Widaman, Rachel Buckley, Michael Properzi, Elizabeth Mormino, Hyun-Sik Yang, Shea J. Andrews, R. Elizabeth Sanders, Neha S. Raghavan, Badri Vardarajan, The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Gerard Schellenberg, Carlos Cruchaga, Jonathan L. Haines, C. Dirk Keene, Andrew J. Saykin, Eric B. Larson, Reisa A. Sperling, Richard Mayeux, David A Bennett, Julie A. Schneider, Paul K. Crane, Angela L. Jefferson, Timothy J. Hohman
Functional characterization of an Alzheimer disease-associated deletion in SORL1. Derek M. Dykxhoorn, Shaina A. Simon, Brian W. Kunkle, Michael L. Cuccaro, Jeffery M. Vance, Holly N. Cukier, and Margaret A. Pericak-Vance

Novel loci for Alzheimer disease identified in ADGC and UK Biobank GWAS datasets imputed with ADSP and TopMed reference panels. John Farrell, Congcong Zhu, Xiaoling Zhang, Adam C. Naj, Li-San Wang, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Kathryn L. Lunetta, and Lindsay A. Farrer
HLA-DQA1*03:01 and DQB1*03:02 are protective alleles for Alzheimer disease, multiple sclerosis, and celiac disease. John Farrell, Congcong Zhu, Xiaoling Zhang, Gyungah R. Jun, Richard Mayeux, Jesse Mez, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Kathryn L. Lunetta, and Lindsay A. Farrer

PRADI Cohort Case-Control Study on Related Factors of Alzheimer’s Disease. Briseida E. Feliciano-Astacio, Gary W. Beecham, Concepcion Silva, Pedro R. Mena, Jovita Inciute, Sergio Tejada, Larry D. Adams, Vanessa Rodriguez, Katrina Celis, Michael Prough, Parker L. Bussies, Carolina Sierra, Maricarmen Contreras, Patricia Manrique, Nereida Feliciano, Angel Chinea, Jacob L. McCauley, Heriberto Acosta, Jeffery M. Vance, Michael L Cuccaro, and Margaret A. Pericak-Vance

The Caribbean-Hispanic Alzheimer’s Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms. Daniel Felsky, Sanjeev Sariya, Julie A. Schneider, David A. Bennett, Philip L. De Jager, Richard Mayeux, and Giuseppe Tosto

A multi-ancestry analysis of Alzheimer’s Disease co-expressed gene networks identifies a common immune signaling pathway regulated by granulocyte-colony stimulating factor (G-CSF). Olivia K. Gardner, George Ling, Derek Van Booven, Patrice L. Whitehead, Kara L. Hamilton-Nelson, Larry D. Adams, Takiyah D. Starks, Aja M. Scott, Katrina Celis, Faina C. Lacroix, Natalia K. Hofmann, Vanessa Rodriguez, Sergio Tejada, Pedro R. Mena, Concepcion Silva-Vergara, Nereida Feliciano, Heriberto Acosta, Eden R. Martin, Jeffery M. Vance, Michael L. Cuccaro, Briseida E. Feliciano-Astacio, Goldie S. Byrd, Jonathan L. Haines, William S. Bush, Gary W. Beecham, Margaret A. Pericak-Vance, and Anthony J. Griswold

Transcriptomic Characterization of a Puerto Rican Alzheimer Disease Cohort Implicates Convergent Immune Related Pathways. Anthony J. Griswold, Olivia K. Gardner, Farid Rajabli, Kara L. Hamilton-Nelson, Larry D. Adams, Vanessa C Rodriguez, Pedro Ramon Mena, Patrice L. Whitehead, Natalia K. Hofmann, Catherine Garcia-Serje, Concepcion Silva-Vergara, Nereida I. Feliciano, Briseida E. Feliciano-Astacio, Heriberto Acosta, Jonathan L. Haines, Jeffery M. Vance, Michael L. Cuccaro, Gary W. Beecham, and Margaret A. Pericak-Vance

Defining Alzheimer’s disease subtypes using polygenic risk scores integrated with genomic and brain transcriptomic profiles. J. Hu, Jaeyoon Chung, Panitch R, Congcong Zhu, Gary W. Beecham, Jesse Mez, Lindsay A. Farrer, T.D. Stein, P.K. Crane, and Gyungah R. Jun
Mechanisms for the protective effect of APOE2 against Alzheimer disease is linked to tau and the classical complement pathway. Gyungah R. Jun, Congcong Zhu, R. Panitch, Jaeyoon Chung, J. Hu, Li-San Wang, Kathryn L. Lunetta, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Gerard D. Schellenberg, T.D. Stein, and Lindsay A. Farrer

Alzheimer’s disease variant portal (ADVP): harmonized genetics data and evidence collection for Alzheimer’s disease. Yuk Yee Leung, Pavel Kuksa, Liming Qu, Yi Zhao, Zivadin Katanic, Amanda B. Kuzma, Wei Fu, Chia-Lun Liu, Pei-chuan Ho, Kai-Teh Tzeng, Otto Valladares, Shin-Yi Chou, Adam C. Naj, Gerard D. Schellenberg and Li-San Wang

Search for Protective Genetic Variants in Alzheimer Disease in the U.S. Mid-Western Amish. Leighanne R. Main, Yuenjoo E. Song, Renee A. Laux, Kristy Miskimen, Michael L. Cuccaro, Paula Ogrocki, Alan J. Lerner, Jeffrey M. Vance, M. Denise Fuzzell, Sarada L. Fuzzell, Jane L. Sewell, Laura J. Caywood, Michael Prough, William K. Scott, Larry D. Adams, Jason E. Clouse, Sharlene D. Herington, Margaret A. Pericak-Vance, and Jonathan L. Haines
Genome-wide association analyses identify genes modifying age-at-onset of Alzheimer’s disease. Eden R. Martin, Shuming Sun, Susan H. Slifer, Adam C. Naj, Xiaoyi R. Gao, and Yi-Ju Li, for the Alzheimer Disease Genetics Consortium (ADGC)
The Alzheimer’s Disease Sequencing Project – Follow Up Study (ADSP-FUS): increasing ethnic diversity in Alzheimer’s genetics research with addition of potential new cohorts. Pedro Ramon Mena, Brian W. Kunkle, Kelley Faber, Katrina Celis, Larry D. Adams, Tatiana M. Foroud, Dolly Reyes-Dumeyer, Amanda B. Kuzma, Adam C. Naj, Eden R. Martin, Clifton L. Dalgard, CLS5, Gerard D. Schellenberg, Li-San Wang, Jeffery M. Vance, Michael L. Cuccaro, Richard Mayeux, Badri N. Vardarajan, and Margaret A. Pericak-Vance

Genome-wide Interaction Study of Smoking in Alzheimer’s Disease. M. Moore, Jaeyoon Chung, M. Rosenthaler, M. Uretsky, A. Abdolmohammadi, N.S. Raghavan, John Farrell, D.A. Bennett, P.K. Crane, M.I. Kamboh, W.A. Kukull, E.B. Larson, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Richard Mayeux, Kathryn L. Lunetta, Lindsay A. Farrer, and Jesse Mez

Development of a massively parallel reporter assay to identify functional regulatory variants in the PICALM Alzheimer disease associated locus. Karen Nuytemans, Derek Van Booven, Derek M. Dykxhoorn, Vance, Margaret A. Pericak-Vance, and Anthony J. Griswold

African and European Local Ancestry surrounding Apolipoprotein E Has a Differential Biological Effect Upon Acute Amyloid Beta Exposure in iPSC-Differentiated Astrocytes. Oded Oron, Krisna S. Maddy, Katrina Celis, Holly N. Cukier, Margaret A. Pericak-Vance, Juan Young, Mathew Blurton-Jones, Anthony J. Griswold Jeffery M. Vance, and Derek M. Dykxhoorn

Novel mechanism underlying the APOE e2 protective effect for Alzheimer disease implicated by integrative genome and transcriptome analysis. R. Panitch, Congcong Zhu, J. Hu, Jaeyoon Chung, T.D. Stein, Lindsay A. Farrer, and Gyungah R. Jun
Cell-type Specific eQTLS (ct-eQTLs) Associated with Alzheimer Disease in Blood and Brain Tissue. D. Patel, Zhang X, and Lindsay A. Farrer

An Alzheimer’s linked loss-of-function CLN5 variant impairs Cathepsin D maturation consistent with a retromer trafficking defect. Yasir H. Qureshi, Vivek M. Patel, Diego E. Berman, Milankumar J. Kothiya, Jessica L. Neufeld, Badri N. Vardarajan, Min Tang, Dolly Reyes-Dumeyer, Rafael Lantigua, Martin Medrano, Richard Mayeux, Scott A. Small, and Christiane Reitz

Genetic Associations with brain amyloidosis. Neha S. Raghavan, Logan Dumitrescu, Elizabeth Mormino, Emily Mahoney, Annie J. Lee, Yizhe Gao, Murat Bilgel, David Goldstein, Theresa Harrison, Corinne D. Engelman, Andrew J. Saykin, Christopher D. Whelan, Jimmy Z. Liu, William Jagust, Marilyn Albert, Sterling Johnson, Hyun-Sik Yang, Keith Johnson, Paul Aisen, Susan M. Resnick, Reisa Sperling, Philip L. De Jager, The Alzheimer’s Disease Neuroimaging Initiative, Julie Schneider, David A. Bennett, Matthew Schrag, Badri N. Vardarajan, Timothy J. Hohman, and Richard Mayeux

Joint linkage and association mapping of preserved cognition in the old-order Amish. Jairo Ramos, James Jaworski, Larry D. Adams, Renee A. Laux, Laura J. Caywood, Michael Prough, Jason E. Clouse, Sharlene D. Herington, Susan H. Slifer, M. Denise Fuzzell, Sarada L. Fuzzell, Jane L. Sewell, Sherri D. Miller, Yeunjoo E. Song, Kristy Miskimen, Leighanne A. Main, Paula Ogrocki, Alan J. Lerner, Jeffery M. Vance, Michael L. Cuccaro, Jonathan L. Haines, Margaret A. Pericak-Vance, and William K. Scott

The role of Native American ancestry in Alzheimer’s disease. Sanjeev Sariya, Miguel Arce Rentería, Jennifer J. Manly, Silvia Mejia Arango, Alejandra Michaels Obregon, Rafael Samper-Ternent, Rebeca Wong, Richard Mayeux, Sandra Barral, and Giuseppe Tosto

Exploring genetic contributors to neuroprotection from AD pathologies: A genome-wide association study. Mabel Seto, Emily R. Mahoney, Logan Dumitrescu, Corinne D. Engelman, Yuetiva Deming, Marilyn Albert, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Angela L. Jefferson, Timothy J. Hohman
Leveraging predicted gene expression data for recapitulation of gene co-expression network analysis associations with AD pathology and cognitive decline. Mabel Seto, Vaibhav A. Janve, Benjamin A. Logsdon, Sara Mostafavi, Logan Dumitrescu, Emily R. Mahoney, Chris Gaiteri, Julie A. Schneider, David A. Bennett, Philip L. De Jager, Timothy J. Hohman
Recruitment Strategies for the Genetics of Alzheimer Disease in the Puerto Rican Population. Concepcion Silva, Pedro R. Mena, Sergio Tejada, Larry D. Adams, Vanessa Rodriguez, Katrina Celis, Michael Prough, Parker L. Bussies, Carolina Sierra, Maricarmen Contreras, Patricia Manrique, Nereida I. Feliciano, Angel Chinea, Jacob L. McCauley, Heriberto Acosta, Jeffery M. Vance, Michael L. Cuccaro, Gary W. Beecham, Margaret A. Pericak-Vance, and Briseida E. Feliciano-Astacio

Longitudinal Assessment of Cognitive Decline in the Amish. Yeunjoo E. Song, Kristy Miskimen, Renee A. Laux, M. Denise Fuzzell, Sarada L. Fuzzell, Jane L. Sewell, Sherri D. Miller, Larry D. Adams, Laura J. Caywood, Michael Prough, Jason E. Close, Sharlene D. Herington, Susan H. Slifer, Jairo Ramos, Jeffery M. Vance, Michael L. Cuccaro, Paula K. Ogrocki, Alan J. Lerner, William K. Scott, Margaret A. Pericak-Vance, and Jonathan L. Haines

The effect of global ancestry and diabetes on the 3MS score in older Puerto Ricans. Sergio J Tejada, Farid Rajabli, Pedro Ramon Mena, Eden R. Martin, Vanessa C. Rodriguez, Katrina Celis, Larry D. Adams, Parker Bussies, Michael Proug, Kara L. Hamilton-Nelson, Concepcion Silva-Vergara, Heriberto Acosta, Jeffery M. Vance, Briseida E. Feliciano-Astacio, Gary W. Beecham, Margaret A. Pericak-Vance, and Michael L. Cuccaro

Identification of differential regulation of European versus African local ancestry haplotypes surrounding ApoEε4. Lipkin Vasquez, Katrina Celis, Derek Van Booven, Natalia K. Hofmann, Farid Rajabli, Anthony J. Griswold, Brown, Margaret A. Pericak-Vance, Karen Nuytemans, and Jeffrey M. Vance
Differential effects of Apolipoprotein E on the molecular and cellular phenotypes associated with Alzheimer’s disease in isogenic human iPSC-derived neurons. Y. You, W.W. Poon, Gyungah R. Jun, Lindsay A. Farrer, and T. Ikezu
Early-Mid Adulthood Measures of HDL, Triglycerides and Fasting Glucose are Associated with Late-onset Alzheimer Disease. Zhang X, T. Tong, A. Chang, T.F.A. Ang, Q. Tao, S. Auerbach, S. Devine, W. Qiu, Jesse Mez, J. Massaro, Kathryn L. Lunetta, R. Au, and Lindsay A. Farrer

Evaluation of Pleiotropy between Breast Cancer and Alzheimer Disease as a Means to Detect Novel AD Susceptibility Loci. Congcong Zhu, Jaeyoon Chung, Jesse Mez, Zhang X, Gyungah R. Jun, Brian W. Kunkle, Eden R. Martin, Margaret A. Pericak-Vance, Richard Mayeux, Jonathan L. Haines, Gerard D. Schellenberg, Kathryn L. Lunetta, and Lindsay A. Farrer

 

Contact Us

Administratively housed at Case Western Reserve University with support from all participating academic institutions

Department of Population and Quantitative Health Sciences

2103 Cornell Road, Suite 2500

Cleveland, Ohio 44106